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Early evolution of the venom system in lizards and snakes
Demonstration that the snakes, iguanians and anguimorphs form a single clade provides overwhelming support for a single, early origin of the venom system in lizards and snakes.
Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.
It is shown here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb and there is a close relationship, both temporal and spatial, between the activation of the Bmp-2 and Hoxd-13 genes in response to retinoic acid and polarizing region grafts, suggesting that expression of the two genes might be linked.
A new technique for identifying sequence heterochrony.
This work describes a new, parsimony-based method, which it is called Parsimov, that greatly increases the utility of the event-pair method for inferring instances of sequence heterochrony.
The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection.
Measuring thigmotaxis in larval zebrafish
Analyzing developmental sequences within a phylogenetic framework.
The method of "event-pair cracking" thereby allows developmental timing data to be analyzed quantitatively within a phylogenetic framework to infer key heterochronic shifts and provides a set of desired features identified by previous authors.
There is no highly conserved embryonic stage in the vertebrates: implications for current theories of evolution and development
It is found that embryos at the tailbud stage – thought to correspond to a conserved stage – show variations in form due to allometry, heterochrony, and differences in body plan and somite number, which foreshadow important differences in adult body form.
Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish.
For the first time, a GR beta-isoform has been identified in a nonhuman animal species, shedding new light on the relevance of this GR splice variant and providing a versatile animal model for studies on the GR system.