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Early evolution of the venom system in lizards and snakes
Demonstration that the snakes, iguanians and anguimorphs form a single clade provides overwhelming support for a single, early origin of the venom system in lizards and snakes.
Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.
It is shown here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb and there is a close relationship, both temporal and spatial, between the activation of the Bmp-2 and Hoxd-13 genes in response to retinoic acid and polarizing region grafts, suggesting that expression of the two genes might be linked.
Translating rodent behavioral repertoire to zebrafish (Danio rerio): Relevance for stress research
A new technique for identifying sequence heterochrony.
This work describes a new, parsimony-based method, which it is called Parsimov, that greatly increases the utility of the event-pair method for inferring instances of sequence heterochrony.
The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
- F. Vonk, N. Casewell, M. Richardson
- BiologyProceedings of the National Academy of Sciences
- 2 December 2013
It is shown that regulatory components of the venom secretory system may have evolved from a pancreatic origin and that venom toxin genes were co-opted by distinct genomic mechanisms, which provides insight into mechanisms of protein evolution under strong selection.
Measuring thigmotaxis in larval zebrafish
Analyzing developmental sequences within a phylogenetic framework.
The method of "event-pair cracking" thereby allows developmental timing data to be analyzed quantitatively within a phylogenetic framework to infer key heterochronic shifts and provides a set of desired features identified by previous authors.
There is no highly conserved embryonic stage in the vertebrates: implications for current theories of evolution and development
- M. Richardson, J. Hanken, G. Wright
- Biology, Environmental ScienceAnatomy and Embryology
- 30 July 1997
It is found that embryos at the tailbud stage – thought to correspond to a conserved stage – show variations in form due to allometry, heterochrony, and differences in body plan and somite number, which foreshadow important differences in adult body form.
Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish.
For the first time, a GR beta-isoform has been identified in a nonhuman animal species, shedding new light on the relevance of this GR splice variant and providing a versatile animal model for studies on the GR system.