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Early evolution of the venom system in lizards and snakes
Among extant reptiles only two lineages are known to have evolved venom delivery systems, the advanced snakes and helodermatid lizards (Gila Monster and Beaded Lizard). Evolution of the venom systemExpand
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Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb.
We show here that bone morphogenetic protein 2 (BMP-2) is involved in patterning the developing chick limb. During early stages of limb development, mesenchymal expression of the Bmp-2 gene isExpand
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The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system
Significance Snake venoms are toxic protein cocktails used for prey capture. To investigate the evolution of these complex biological weapon systems, we sequenced the genome of a venomous snake, theExpand
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Translating rodent behavioral repertoire to zebrafish (Danio rerio): Relevance for stress research
The current study provides a detailed description of the pattern of exploratory behaviors encountered in adult zebrafish when exposed to a novel/unfamiliar environment using the light/dark box andExpand
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A new technique for identifying sequence heterochrony.
Sequence heterochrony (changes in the order in which events occur) is a potentially important, but relatively poorly explored, mechanism for the evolution of development. In part, this is because ofExpand
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Measuring thigmotaxis in larval zebrafish
One of the most commonly used behavioral endpoints measured in preclinical studies using rodent models is thigmotaxis (or "wall-hugging"). Thigmotaxis is a well-validated index of anxiety in animalsExpand
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There is no highly conserved embryonic stage in the vertebrates: implications for current theories of evolution and development
Abstract Embryos of different species of vertebrate share a common organisation and often look similar. Adult differences among species become more apparent through divergence at later stages. SomeExpand
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Analyzing developmental sequences within a phylogenetic framework.
Heterochrony is important as a potential mechanism of evolutionary change. However, the analysis of developmental timing data within a phylogenetic framework to identify important shifts has provenExpand
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Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish.
Low oxygen levels (hypoxia) play a role in clinical conditions such as stroke, chronic ischemia, and cancer. To better understand these diseases, it is crucial to study the responses of vertebratesExpand
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Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code.
It is generally assumed that the characteristic deregionalized body plan of species with a snake-like morphology evolved through a corresponding homogenization of Hox gene expression domains alongExpand
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