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Determination of release and uptake parameters from electrically evoked dopamine dynamics measured by real-time voltammetry
Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6
The SLC6 family is a diverse set of transporters that mediate solute translocation across cell plasma membranes by coupling solute transport to the cotransport of sodium and chloride down their…
LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake
Mutagenesis experiments on human SERT and DAT indicate that both the desipramine-binding site and its inhibition mechanism are probably conserved in the human neurotransmitter transporters.
Preferential Increases in Nucleus Accumbens Dopamine after Systemic Cocaine Administration Are Caused by Unique Characteristics of Dopamine Neurotransmission
The lower rates for dopamine release and uptake measured in the nucleus accumbens were found to underlie the preferential increase in extracellular dopamine after cocaine, explaining the paradox that cocaine more effectively increases accumbal dopamine despite identical effects on the dopamine transporter in the two regions.
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures
- Zheng Zhou, J. Zhen, N. Karpowich, C. J. Law, M. Reith, Da-Neng Wang
- Biology, ChemistryNature Structural &Molecular Biology
The crystal structures of LeuT, a bacterial SERT homolog, in complex with sertraline, R-fluoxetine or S-fluxetine are reported and it is reported that the SSRI halogens all bind to exactly the same pocket within LeoT.
The Role of N-Glycosylation in Function and Surface Trafficking of the Human Dopamine Transporter*
Non-glycosylated DAT at the cell surface displays appreciably reduced catalytic activity and altered inhibitor sensitivity compared with wild type, and did not transport dopamine as efficiently as wild-type DAT as judged from the sharp reduction in uptake Vmax.
Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice.
- M. Benuck, A. Lajtha, M. Reith
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 October 1987
There was a significant correlation between animals' locomotor stimulation and their brain cocaine concentration, indicating that differences in cocaine levels in the brain between animals contribute to their different behavioral response; however, the correlation analysis also indicated the role of other factors determining the locomotor response to cocaine.
Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia.
In humans, loss-of-function SLC6A3 mutations that impair DAT-mediated dopamine transport activity are associated with an early-onset complex movement disorder, and identification of the molecular basis of IPD suggests SLC 6A3 as a candidate susceptibility gene for other movement disorders associated with parkinsonism and/or dystonic features.
Concurrent Autoreceptor-Mediated Control of Dopamine Release and Uptake during Neurotransmission: An In Vivo Voltammetric Study
- Qun Wu, M. Reith, Q. D. Walker, C. Kuhn, F. Carroll, P. Garris
- BiologyThe Journal of Neuroscience
- 15 July 2002
It is concluded that presynaptic DA autoreceptors concurrently downregulate release and upregulate uptake, and that the mechanisms are also independently controlled during neurotransmission.
Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of…
There is considerable crosstalk between monoamine systems occurring upon systemic administration of uptake blockers, and the VTA and NACC are notably different in the time course of the DA effect (long-lasting versus transient).