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Nitric oxide in skeletal muscle
REACTIVE oxygen intermediates modulate skeletal muscle contraction1,2, but little is known about the role of nitric oxide (NO). Here we show that rat skeletal muscle expresses neuronal-type NOExpand
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TNF‐α acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle
  • Y. Li, Y. Chen, +4 authors M. Reid
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 March 2005
Atrogin1/MAFbx is an ubiquitin ligase that mediates muscle atrophy in a variety of catabolic states. We recently found that H2O2 stimulates atrogin1/MAFbx gene expression. Since the cytokine tumorExpand
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Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse
1 We used intact single fibres from a mouse foot muscle to study the role of oxidation‐reduction in the modulation of contractile function. 2 The oxidant hydrogen peroxide (H2O2, 100‐300 μM) forExpand
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Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro.
We hypothesized that muscle fiber bundles produce reactive oxygen intermediates and that reactive oxidant species contribute to muscular fatigue in vitro. Fiber bundles from rat diaphragm wereExpand
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Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't.
  • M. Reid
  • Chemistry, Medicine
  • Journal of applied physiology
  • 1 February 2001
Over the past decade, reactive oxygen species (ROS) and nitric oxide (NO) derivatives have been established as physiological modulators of skeletal muscle function. This mini-review addresses theExpand
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Role of nitric oxide in skeletal muscle: synthesis, distribution and functional importance.
  • M. Reid
  • Biology, Medicine
  • Acta physiologica Scandinavica
  • 1 February 1998
Over the last two decades, nitric oxide (NO) has been established as a novel mediator of biological processes, ranging from vascular control to long-term memory, from tissue inflammation to penileExpand
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N-acetylcysteine inhibits muscle fatigue in humans.
N-acetylcysteine (NAC) is a nonspecific antioxidant that selectively inhibits acute fatigue of rodent skeletal muscle stimulated at low (but not high) tetanic frequencies and that decreasesExpand
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CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function
MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and function. We reportExpand
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Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals.
We have tested the hypothesis that diaphragm muscle fibers release superoxide anion radicals (O2-.) into the extracellular space. Fiber bundles were isolated from rat diaphragm and incubated inExpand
  • 317
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Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha.
Skeletal muscle atrophy and weakness are thought to be stimulated by tumor necrosis factor alpha (TNF-alpha) in a variety of chronic diseases. However, little is known about the direct effects ofExpand
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