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Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds
For budding yeast to ensure formation of only one bud, cells must polarize toward one, and only one, site. Polarity establishment involves the Rho family GTPase Cdc42, which concentrates atExpand
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A mathematical model of glutathione metabolism
BackgroundGlutathione (GSH) plays an important role in anti-oxidant defense and detoxification reactions. It is primarily synthesized in the liver by the transsulfuration pathway and exported toExpand
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Homeostatic mechanisms in dopamine synthesis and release: a mathematical model
BackgroundDopamine is a catecholamine that is used as a neurotransmitter both in the periphery and in the central nervous system. Dysfunction in various dopaminergic systems is known to be associatedExpand
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The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
BackgroundAcetaminophen (N-acetyl-para-aminophenol) is the most widely used over-the-counter or prescription painkiller in the world. Acetaminophen is metabolized in the liver where a toxic byproductExpand
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The biological significance of substrate inhibition: A mechanism with diverse functions
Many enzymes are inhibited by their own substrates, leading to velocity curves that rise to a maximum and then descend as the substrate concentration increases. Substrate inhibition is often regardedExpand
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A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism.
Impaired folate-mediated 1-carbon metabolism has been linked to multiple disease outcomes. A better understanding of the nutritional and genetic influences on this complex biochemical pathway isExpand
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Serotonin synthesis, release and reuptake in terminals: a mathematical model
BackgroundSerotonin is a neurotransmitter that has been linked to a wide variety of behaviors including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessiveExpand
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A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH
In a previous study, a model was developed to investigate the release of luteinizing hormone (LH) from pituitary cells in response to a short pulse of gonadotropin-releasing hormone (GnRH). The modelExpand
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A Mathematical Model of the Folate Cycle
A mathematical model is developed for the folate cycle based on standard biochemical kinetics. We use the model to provide new insights into several different mechanisms of folate homeostasis. TheExpand
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Neural Tube Defects and Folate Pathway Genes: Family-Based Association Tests of Gene–Gene and Gene–Environment Interactions
Background Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect.Expand
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