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A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-α, and Contact Sensitizers
We investigated the involvement of mitogen-activated protein kinases (MAPKs) in the maturation of CD83− dendritic cells (DC) derived from human blood monocytes. Maturating agents such as LPS andExpand
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Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
OBJECTIVE The purpose of this study was to investigate whether prostaglandin E2 (PGE2) induces Signal transducer and activator of transcription 3 (Stat3) activation in neonatal rat ventricularExpand
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The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction
Polymorphisms of the cytochrome P450 2D6 (CYP2D6) gene affecting enzyme activity are involved in interindividual variability in drug efficiency/toxicity. Four phenotypic groups are found in theExpand
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Psychological distress in fibromyalgia patients: a role for catechol-O-methyl-transferase Val158met polymorphism.
OBJECTIVE Fibromyalgia (FM) has been related to biochemical alterations, central pain sensitization and psychological distress. Among genetic and environmental hypotheses, a role was suggested forExpand
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Epidermal growth factor induces hypertrophic responses and Stat5 activation in rat ventricular cardiomyocytes.
Epidermal growth factor (EGF) was tested for its ability to promote hypertrophic responses in neonatal rat ventricular cardiomyocytes. Exposure of these cells to 100 n m EGF for 2-18 h resulted in aExpand
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Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes.
OBJECTIVE Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte function is not yet completelyExpand
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First Evidence of a Polygenic Susceptibility to Pain in a Pediatric Cohort
BACKGROUND:There is currently no evidence about the genetic bases of postoperative pain variability in children. METHODS:We prospectively followed a cohort of 168 children after orthopedic orExpand
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Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes.
Incubation of cultured, neonatal rat ventricular cardiomyocytes with 100 nM phorbol 12-myristate-13-acetate (PMA) induced a transient suppression of PP2A activity at 5 min, an effect that wasExpand
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