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Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO.
Circadian rhythms of mammals are timed by an endogenous clock with a period of about 24 hours located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Light synchronizes this clock to theExpand
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5HT1B Receptor Agonists Inhibit Light-Induced Phase Shifts of Behavioral Circadian Rhythms and Expression of the Immediate–Early Gene c-fos in the Suprachiasmatic Nucleus
The suprachiasmatic nucleus (SCN) is a circadian oscillator and a critical component of the mammalian circadian system. It receives afferents from the retina and the mesencephalic raphe. RetinalExpand
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Serotonin modulates photic responses in the hamster suprachiasmatic nuclei
The aim of the present study was to examine the effects of serotonin agonists on three elements of the photic response in the hamster suprachiasmatic nuclei (SCN). Both serotonin and the selectiveExpand
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5-HT1B Receptor–Mediated Presynaptic Inhibition of Retinal Input to the Suprachiasmatic Nucleus
The suprachiasmatic nucleus (SCN) receives glutamatergic afferents from the retina and serotonergic afferents from the midbrain, and serotonin (5-HT) can modify the response of the SCN circadianExpand
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Serotonergic innervation of the hypothalamic suprachiasmatic nucleus and photic regulation of circadian rhythms
Converging lines of evidence have firmly established that the hypothalamic suprachiasmatic nucleus (SCN) is a light‐entrainable circadian oscillator in mammals, critically important for theExpand
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Modulation of light-induced C-Fos expression in the suprachiasmatic nuclei by 5-HT1A receptor agonists
In previous studies, we showed that light-induced Fos protein expression in the ventrolateral SCN is markedly inhibited by the nonselective serotonergic, quipazine. The present experiments wereExpand
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Glutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes
A procedure is described for the isolation of intact hippocampal mossy fiber synaptosomes. Electron microscopic examination revealed numerous synaptosomal profiles which are clearly of mossy fiberExpand
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Serotonergic inhibition of light-induced fos protein expression and extracellular glutamate in the suprachiasmatic nuclei
The present experiments were undertaken to explore a role for serotonin (5-HT) in modulating photic signal transduction and extracellular glutamate (Glu) concentration in the suprachiasmatic nucleiExpand
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cGMP-dependent protein kinase inhibitor blocks light-induced phase advances of circadian rhythms in vivo
The suprachiasmatic nucleus (SCN) contains the primary mammalian circadian clock. Light synchronizes these circadian rhythms through a mechanism involving the release of excitatory amino acids (EAA)Expand
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Light increases Fos-related protein immunoreactivity in the rat suprachiasmatic nuclei
  • M. Rea
  • Biology, Medicine
  • Brain Research Bulletin
  • 1 December 1989
Fifteen minutes of bright, white light exposure at midsubjective night resulted in a marked increase in both the number and stain density of c-fos protein (Fos)-immunoreactive neurons in theExpand
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