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GENEPOP (version 1.2): population genetic software for exact tests and ecumenicism
AN EXACT TEST FOR POPULATION DIFFERENTIATION
Testing differentiation in diploid populations.
The power of FST-estimator tests and of allelic goodness offit tests are similar when sampling is balanced, and higher than the power of genotypic goodness of fit tests.
Testing heterozygote excess and deficiency.
Different exact tests, appropriate for small sample size and large number of alleles, are proposed in this perspective, and their properties are evaluated by power comparisons.
GENEPOP (version 3.3): population genetics software for exact tests and ecumenicism. Updated from Raymond, M., and F. Rousset. 1995
Insecticide Resistance and Dominance Levels
The time has come to focus on fitness dominance levels in the presence and absence of insecticide, according to a general formula forestimating dominance on a scale of 0 to 1.
A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non–homologous to the ace gene Drosophila
- M. Weill, P. Fort, A. Berthomieu, M. Dubois, N. Pasteur, M. Raymond
- BiologyProceedings of the Royal Society of London…
- 7 October 2002
Two AChE loci are identified in the genome of Anopheles gambiae, one (ACE–1) being a new locus and the other (ace–2) being homologous to the gene previously described in Drosophila, indicating the existence of a second ace locus.
The unique mutation in ace‐1 giving high insecticide resistance is easily detectable in mosquito vectors
A three‐dimension structure model of AChE is presented, showing that this unique substitution is localized in the oxyanion hole, explaining the insecticide insensitivity and its interference with the enzyme catalytic functions.
The kdr mutation occurs in the Mopti form of Anopheles gambiaes.s. through introgression
It is concluded that the kdr mutation in the M taxon is not an independent mutation event, and is best explained by an introgression from the S taxon.