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Molecular basis of substrate-induced permeation by an amino acid antiporter
Transporters of the amino acid, polyamine and organocation (APC) superfamily play essential roles in cell redox balance, cancer, and aminoacidurias. The bacterial L-arginine/agmatine antiporter,Expand
Substrate Binding Tunes Conformational Flexibility and Kinetic Stability of an Amino Acid Antiporter*
We used single molecule dynamic force spectroscopy to unfold individual serine/threonine antiporters SteT from Bacillus subtilis. The unfolding force patterns revealed interactions and energyExpand
Functional and Structural Characterization of the First Prokaryotic Member of the L-Amino Acid Transporter (LAT) Family
We have identified YkbA from Bacillus subtilis as a novel member of the l-amino acid transporter (LAT) family of amino acid transporters. The protein is ∼30% identical in amino acid sequence to theExpand
High-throughput single-molecule force spectroscopy for membrane proteins.
Atomic force microscopy-based single-molecule force spectroscopy (SMFS) is a powerful tool for studying the mechanical properties, intermolecular and intramolecular interactions, unfolding pathways,Expand
Role of Transmembrane Domain 8 in Substrate Selectivity and Translocation of SteT, a Member of the l-Amino Acid Transporter (LAT) Family*
System l-amino acid transporters (LAT) belong to the amino acid, polyamine, and organic cation superfamily of transporters and include the light subunits of heteromeric amino acid transporters andExpand
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140Expand
Projection Structure of a Member of the Amino Acid/Polyamine/Organocation Transporter Superfamily*
The l-arginine/agmatine antiporter AdiC is a key component of the arginine-dependent extreme acid resistance system of Escherichia coli. Phylogenetic analysis indicated that AdiC belongs to the aminoExpand
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors.
Adhesion of pathogenic bacteria to target cells is a prerequisite for colonization and further infection. The main adhesins of the emerging sexually transmitted pathogen Mycoplasma genitalium, P140Expand
Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium
Mycoplasma genitalium, the causative agent of non‐gonococcal urethritis and pelvic inflammatory disease in humans, is a small eubacterium that lacks a peptidoglycan cell wall. On the surface of itsExpand
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