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Secondary metabolites of fungi from marine habitats.
TLDR
An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.
Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment.
TLDR
The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3).
Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture
An established culture of Aspergillus fumigatus MBC-F1-10 proved to be very receptive to external stimuli and reacted with the production of secondary metabolites which were undetectable when the
Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert.
TLDR
Genome mining-targeted discovery of new natural products from microbes obtained from extreme environments has led to the identification of a gene cluster directing the biosynthesis of a new lasso peptide, designated as chaxapeptin 1, in the genome of Streptomyces leeuwenhoekii strain C58 isolated from the Atacama Desert.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
TLDR
Three natural products, viz. acetylglucopetunidin, isoxanthohumol and ellagic acid, which are widely available in many edible fruits, obey both Lipinski's and Veber's rules of drug-likeness and thus possess high degrees of predicted bioavailability are suggested as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics in the near future.
An online resource for marine fungi
TLDR
This article reviews knowledge of marine fungi covering a wide range of topics: their higher classification, ecology and world distribution, role in energy transfer in the oceans, origin and new chemical structures.
Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09
TLDR
Three dibenzofurans hitherto undescribed from nature and one known butyrolactone were isolated from the extract of the ascomycete Super1F1-09 isolate from the Fijian marine sponge Acanthella cavernosa and all compounds had moderate inhibitory properties against epidermal growth factor receptor tyrosine kinase.
Antimicrobial Activity of Three Ulva Species Collected from Some Egyptian
TLDR
Members of the class Ulvophyceae, collected from tidal and intertidal zone of Mediterranean sea shores during April 2011 and extracted in ethanol, could serves as useful source of new antimicrobial agents.
Chaxamycins A-D, bioactive ansamycins from a hyper-arid desert Streptomyces sp.
Streptomyces sp. strain C34, isolated from soil collected in the Chilean hyper-arid Atacama Desert, was cultured on different media, resulting in the isolation and identification of four new
Opuntia ficus-indica cladodes as a functional ingredient: bioactive compounds profile and their effect on antioxidant quality of bread
TLDR
Substitution of wheat flour by the cladodes powder at 5% level was optimal for improving the total phenolics content and the antioxidant potential of bread without having any negative effect on its sensory acceptability.
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