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Theoretical Impact of the Injection of Material Into the Myocardium: A Finite Element Model Simulation
Background— To treat cardiac injuries created by myocardial infarcts, current approaches seek to add cells and/or synthetic extracellular matrices to the damaged ventricle to restore function.Expand
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A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.
A non-invasive method for estimating regional myocardial contractility in vivo would be of great value in the design and evaluation of new surgical and medical strategies to treat and/or preventExpand
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Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation.
BACKGROUND Myocardium undergoes complex cellular and histochemical alterations after acute myocardial infarction. These structural changes directly affect the mechanical stiffness of infarcted andExpand
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A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns.
A finite element (FE) simulation-based method was developed in this study that can automatically optimize the injection pattern of the polymeric "inclusions" according to a specific objective function, using commercially available software tools. Expand
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MRI-based finite-element analysis of left ventricular aneurysm.
Tagged MRI and finite-element (FE) analysis are valuable tools in analyzing cardiac mechanics. To determine systolic material parameters in three-dimensional stress-strain relationships, we usedExpand
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The biomechanics of arterial elastin.
Uniaxial mechanical experiments have shown that a neo-Hookean/Gaussian model is suitable to describe the mechanics of arterial elastin networks [Gundiah, N., Ratcliffe, M.B., Pruitt, L.A., 2007.Expand
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A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.
BACKGROUND Infarcted regions of myocardium exhibit functional impairment ranging in severity from hypokinesis to dyskinesis. We sought to quantify the effects of injecting a calciumExpand
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Large animal model of left ventricular aneurysm.
In 28 Dorsett sheep, ligation of the distal homonymous (equivalent to human left anterior descending) and second diagonal coronary arteries produced a constant transmural infarct of 22.9% +/- 2.5%Expand
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Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.
BACKGROUND The global left ventricular dysfunction characteristic of left ventricular aneurysm is associated with muscle fiber stretching in the adjacent noninfarcted (border zone) region duringExpand
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Changes in left ventricular systolic wall stress during biventricular circulatory assistance.
Extracorporeal membrane oxygenation (ECMO) reduces the systolic stress integral (SSI) in the normal left ventricle. We tested the hypothesis that the SSI does not decrease in poorly contracting,Expand
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