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A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow
It is hypothesize that this population of Sca-1+lin−CD45− very small embryonic-like (VSEL) stem cells is deposited early during development in BM and could be a source of pluripotent stem cells for tissue/organ regeneration.
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
- J. Ratajczak, M. Wysoczynski, F. Hayek, A. Janowska-Wieczorek, M. Ratajczak
- 30 August 2006
The pleiotropic effects of MV that are important for communication between cells, as well as the role of MV in carcinogenesis, coagulation, immune responses and modulation of susceptibility/infectability of cells to retroviruses or prions are discussed.
CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion
The role of the SDF-1–CXCR4 axis in regulating the metastatic behaviour of tumour cells is focused on and the molecular mechanisms that are essential to this process are discussed.
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF‐1–CXCR4 Axis
It is suggested that strategies aimed at modulating the SDF‐1–CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer
- A. Janowska-Wieczorek, M. Wysoczynski, M. Ratajczak
- Biology, MedicineInternational journal of cancer
- 20 February 2005
It is suggested that PMV play an important role in tumor progression/metastasis and angiogenesis in lung cancer.
Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal‐Derived Factor‐1‐CXCR4 and Hepatocyte Growth Factor‐c‐met Axes and Involves Matrix Metalloproteinases
In vitro results suggest that the SDF‐1‐CXCR4 and HGF‐c‐met axes, along with MMPs, may be involved in recruitment of expanded MSCs to damaged tissues.
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
ES-MV isolated from murine ES cells in serum-free cultures significantly enhanced survival and improved expansion of murine HPC, and upregulated the expression of early pluripotent and early hematopoietic stem cells in these cells.
Mobilization of CD34/CXCR4+, CD34/CD117+, c-met+ Stem Cells, and Mononuclear Cells Expressing Early Cardiac, Muscle, and Endothelial Markers Into Peripheral Blood in Patients With Acute Myocardial…
The study demonstrates in the setting of STEMI a marked mobilization of mononuclear cells expressing specific cardiac, muscle, and endothelial markers as well as CD34/CXCR4+ andCD34/CD117+ and c-met+ stem cells and shows that stromal cell–derived factor-1 is an important factor influencing the mobilization.
Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of…
In patients with AMI and impaired LveF, treatment with BM cells does not lead to a significant improvement of LVEF or volumes, and there was however a trend in favour of cell therapy in patients with most severely impaired LVEf and longer delay between the symptoms and revascularization.
The pleiotropic effects of the SDF-1–CXCR4 axis in organogenesis, regeneration and tumorigenesis
- M. Ratajczak, E. Zuba-Surma, M. Kucia, R. Reca, W. Wojakowski, J. Ratajczak
- 1 November 2006
Experimental evidence indicates that pharmacological modulation of the SDF-1–CXCR4 axis may lead to the development of new therapeutic strategies to enhance mobilization of CxCR4+ NSC and their homing to damaged organs as well as inhibition of the metastasis of CX CR4+ cancer cells.