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Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
TLDR
Bapineuzumab did not improve clinical outcomes in patients with Alzheimer's disease, despite treatment differences in biomarkers observed in APOE ε4 carriers. Expand
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
TLDR
It is hypothesized that a saturable mechanism mediates CSF leptin transport, and that reduced efficiency of brain leptin delivery among obese individuals with high plasma leptin levels results in apparent leptin resistance. Expand
Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.
TLDR
These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms. Expand
Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis
TLDR
The increased risk of ARIA among APOE ɛ4 carriers, its association with high bapineuzumab dose, and its timecourse in relation to dosing suggest an association between ARIA and alterations in vascular amyloid burden. Expand
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
TLDR
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism. Expand
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
TLDR
Two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 are reported and could partially explain the high frequency of alcohol-related pancreatitis in men. Expand
The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
TLDR
Understanding the neurobiology of the stress response has begun to help patients with stress disorders, and open label studies suggest that guanfacine may be especially helpful in treating children and adolescents who have experienced trauma. Expand
A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence.
TLDR
Prazosin holds promise as a pharmacologic treatment for AD and deserves further evaluation in a larger controlled trial. Expand
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
TLDR
Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease. Expand
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