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Tau is a candidate gene for chromosome 17 frontotemporal dementia
Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP‐17), a recently defined disease entity, is clinically characterized by personality changes sometimes associated with psychosis,Expand
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Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
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Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
BACKGROUND Bapineuzumab, a humanized anti-amyloid-beta monoclonal antibody, is in clinical development for the treatment of Alzheimer's disease. METHODS We conducted two double-blind, randomized,Expand
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Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
The adipocyte hormone, leptin (OB protein), is proposed to be an “adiposity signal” that acts in the brain to lower food intake and adiposity1–5. As plasma leptin levels are elevated in mostExpand
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Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study.
OBJECTIVE Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stressExpand
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Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since theExpand
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The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
Research on the neurobiology of the stress response in animals has led to successful new treatments for Post-Traumatic Stress Disorder (PTSD) in humans. Basic research has found that high levels ofExpand
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A pilot trial of the alpha-1 adrenergic antagonist, prazosin, for alcohol dependence.
BACKGROUND Current medications for alcohol dependence (AD) show only modest efficacy. None target brain noradrenergic pathways. Theory and preclinical evidence suggest that noradrenergic circuits mayExpand
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Galantamine in AD
Background: Galantamine is a reversible, competitive cholinesterase inhibitor that also allosterically modulates nicotinic acetylcholine receptors. These mechanisms of action provided the rationaleExpand
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Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease
Patients with Alzheimer's disease (AD) have elevations of fasting plasma insulin that are hypothesized to be associated with disrupted brain insulin metabolism. We examined paired fasted plasma andExpand
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