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- Publications
- Influence
Cigarette Smoking and Plasma Levels of Nicotine
THE changes in blood levels and tissue distribution of nicotine and its metabolites have been studied in experimental animals after administration of tobacco smoke or smoking doses of nicotine1–3,… Expand
Source of ‘Serotonin’ in Serum
RAPPORT et al.1 prepared from beef serum a vasoconstrictor substance which was called ‘serotonin’. By following the pharmacological activity through various stages from serum itself to the final… Expand
Partial agonist action of clonidine on prejunctional and postjunctional α-adrenoceptors
- I. C. Medgett, M. McCulloch, M. Rand
- Chemistry
- Naunyn-Schmiedeberg's Archives of Pharmacology
- 1 October 1978
SummaryThe effects of clonidine on prejunctional α-adrenoceptors in guinea-pig atria and postjunctional α-adrenoceptors in rabbit aorta were studied and compared.1.In isolated aortic strips,… Expand
Pharmacological Actions of Synthetic 5-Hydroxytryptamine (Serotonin, Thrombocytin)
RECENTLY1,2 we reported the actions of serum vasoconstrictor, partially purified by the method of M. M. Rapport3. The evidence at the time strongly indicated that all the pharmacological actions… Expand
New Evidence for a Cholinergic Process in Sympathetic Transmission
RECENTLY a cholinergic mechanism has been proposed in sympathetic transmission1–3. This suggestion was based on the following pieces of evidence. Sympathetic nerves contain cholinergic fibres2.… Expand
Effect of the Rate of Elimination of Digoxigenin in the Guinea Pig on the Determination of its Lethal Dose
- M. Rand, A. Stafford
- Medicine
- Nature
- 7 March 1959
WHEN a drug is given by intravenous infusion it is not possible to define its lethal dose if it is detoxified rapidly, because the apparent lethal dose will depend on the rate of administration of… Expand
INVOLVEMENT OF α1‐ADRENOCEPTORS IN CHRONOTROPIC RESPONSES TO ENDOGENOUSLY RELEASED AMINES IN THE PITHED RAT
- A. De Luca, M. Rand
- Chemistry, Medicine
- Clinical and experimental pharmacology…
- 1 January 1988
1. In pithed rats, yohimbine (1 mg/kg i.v.) enhanced the positive chronotropic responses to spinal stimulation of cardiac sympathetic nerves with eight pulses delivered at 2 or 4 Hz, indicating that… Expand
A Method for determining the Duration of Action of the Cardiac Glycosides
- M. Rand, A. Stafford
- Medicine
- Nature
- 11 February 1956
THE determination of the duration of action of the cardiac glycosides has depended mainly on toxicity experiments which require large numbers of animals. The Hatcher method1 depends on the difference… Expand