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A default mode of brain function.
A baseline or control state is fundamental to the understanding of most complex systems. Defining a baseline state in the human brain, arguably our most complex system, poses a particular challenge.Expand
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The human brain is intrinsically organized into dynamic, anticorrelated functional networks.
During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate theExpand
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Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In thisExpand
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Searching for a baseline: Functional imaging and the resting human brain
Functional brain imaging in humans has revealed task-specific increases in brain activity that are associated with various mental activities. In the same studies, mysterious, task-independentExpand
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Distinct brain networks for adaptive and stable task control in humans
Control regions in the brain are thought to provide signals that configure the brain's moment-to-moment information processing. Previously, we identified regions that carried signals related toExpand
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Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function
Medial prefrontal cortex (MPFC) is among those brain regions having the highest baseline metabolic activity at rest and one that exhibits decreases from this baseline across a wide variety ofExpand
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Common Blood Flow Changes across Visual Tasks: II. Decreases in Cerebral Cortex
Nine previous positron emission tomography (PET) studies of human visual information processing were reanalyzed to determine the consistency across experiments of blood flow decreases during activeExpand
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Evidence for a frontoparietal control system revealed by intrinsic functional connectivity.
Two functionally distinct, and potentially competing, brain networks have been recently identified that can be broadly distinguished by their contrasting roles in attention to the external worldExpand
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Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems.
On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved inExpand
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Subgenual prefrontal cortex abnormalities in mood disorders
Pathological disturbances of mood may follow a 'bipolar' course, in which normal moods alternate with both depression and mania, or a 'unipolar' course, in which only depression occurs1–3. BothExpand
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