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A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium
We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in theExpand
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Multiple extracellular signals are required for long-term oligodendrocyte survival.
We showed previously that oligodendrocytes and their precursors require continuous signalling by protein trophic factors to avoid programmed cell death in culture. Here we show that three classes ofExpand
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Cell death and control of cell survival in the oligodendrocyte lineage
Dead cells are observed in many developing animal tissues, but the causes of these normal cell deaths are mostly unknown. We show that about 50% of oligodendrocytes normally die in the developing ratExpand
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Programmed Cell Death in Animal Development
We thank P. Golstein, R. Horvitz, A. Mudge, and R. Parnaik for helpful comments on the manuscript; J. Scholes for providing the drawings for Figure 2Figure 2; and J.-C. Ameisen, J. Burne, P.Expand
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A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development.
The timing of oligodendrocyte differentiation is thought to depend on an intrinsic clock in oligodendrocyte precursor cells that counts time or cell divisions and limits precursor cell proliferation.Expand
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Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture
The various cell types in a multicellular animal differentiate on a predictable schedule but the mechanisms responsible for timing cell differentiation are largely unknown. We have studied aExpand
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An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism
BACKGROUND Simple epithelia encase developing embryos and organs. Although these epithelia consist of only one or two layers of cells, they must provide tight barriers for the tissues that theyExpand
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Social controls on cell survival and cell death
  • M. Raff
  • Biology, Medicine
  • Nature
  • 2 April 1992
Programmed cell death occurs in most animal tissues at some stage of their development, but the molecular mechanism by which it is executed is unknown. For some mammalian cells, programmed deathExpand
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Programmed cell death and the control of cell survival: lessons from the nervous system.
During the development of the vertebrate nervous system, up to 50 percent or more of many types of neurons normally die soon after they form synaptic connections with their target cells. This massiveExpand
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Axonal Self-Destruction and Neurodegeneration
Neurons seem to have at least two self-destruct programs. Like other cell types, they have an intracellular death program for undergoing apoptosis when they are injured, infected, or not needed. InExpand
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