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The effects of undernutrition, in utero, on reproductive function in adult male and female sheep.
Glucocorticoid metabolism and reproduction: a tale of two enzymes.
Evidence indicates that follicular fluid contains endogenous modulators of cortisol metabolism by 11 beta HSD1, the concentrations of which are associated with the clinical outcome of assisted conception cycles and are altered in cystic ovarian disease.
Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep
Programming of adult cardiovascular function after early maternal undernutrition in sheep.
- G. Gopalakrishnan, D. Gardner, M. Symonds
- Medicine, BiologyAmerican journal of physiology. Regulatory…
- 1 July 2004
Early NR has been shown to program aspects of cardiovascular control and adipocyte function in adult sheep through maternal dietary intervention.
Oestrogen formation and connective tissue growth factor expression in rat granulosa cells.
Connective tissue growth factor (CTGF) gene expression in GC is under local control by oestrogen whose effect (positive or negative) is modulated by FSH, which helps explain why gene expression of CTGF and P450(arom) diverge in FSH-induced PO follicles and has implications for oestrogensic regulation ofCTGF formation elsewhere in the body.
Effects of nutrition and environmental factors on the fetal programming of the reproductive axis.
Although reproductive performance is clearly influenced by prenatal factors, much further work is required to identify the relationships between developmental abnormalities and adult reproductive function and to elucidate further the critical windows in development and the mechanisms by which environmental factors affect the reproductive organs of developing offspring.
Thyroid hormone signaling in human ovarian surface epithelial cells.
- M. Rae, O. Gubbay, A. Kostogiannou, D. Price, H. Critchley, S. Hillier
- Biology, MedicineThe Journal of clinical endocrinology and…
The ovarian surface is a potential T3 target, and T3 exerts direct inflammatory effects on OSE cell function in vitro, which could help explain suggested epidemiological links between hyperthyroidism and ovarian cancer.
Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro
- J. Dearling, Jason S. Lewis, G. Mullen, M. Rae, J. Zweit, P. Blower
- BiologyEuropean Journal of Nuclear Medicine
- 1 July 1998
It is proposed that by modifying the ligand to increase its electron donor strength (for example by adding alkyl functionality or replacing sulphur ligands with oxygen ligands), the copper complexes will become less easily reduced and tracers with selectivity for hypoxic tissues could thus be developed.
Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses.
It is demonstrated that undernutrition before and during folliculogenesis can delay fetal follicular development.
Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro.
Control of LOX at endocrine, paracrine, and autocrine levels within the ovary is indicated and coordinated regulation of ovarian extracellular matrix during follicular development is suggested, with FSH determining whether local factors act as stimulators or inhibitors ofLOX.