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The effects of undernutrition, in utero, on reproductive function in adult male and female sheep.
The aim of this study was to determine the effects of maternal undernutrition during pregnancy on adult reproductive function in male and female offspring. Groups of ewes were fed rations providingExpand
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Glucocorticoid metabolism and reproduction: a tale of two enzymes.
Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta HSD).Expand
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Oestrogen formation and connective tissue growth factor expression in rat granulosa cells.
Ovarian follicular development involves continual remodelling of the extracellular matrix (ECM) forming the basement membrane and intercellular framework that support granulosa cell (GC) growth andExpand
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Effects of nutrition and environmental factors on the fetal programming of the reproductive axis.
Research from a wide range of scientific disciplines has shown that the reproductive performance of animals in adult life is determined, in part, by a variety of extraneous influences acting atExpand
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Effect of maternal undernutrition during pregnancy on early ovarian development and subsequent follicular development in sheep fetuses.
Gonad development in female sheep fetuses is thought to occur in a number of key stages. The aim of this study was to determine the effects of maternal undernutrition, applied at one or more of theseExpand
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Programming of adult cardiovascular function after early maternal undernutrition in sheep.
The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate the association betweenExpand
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Thyroid hormone signaling in human ovarian surface epithelial cells.
CONTEXT Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectively). OvarianExpand
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Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro
Abstract The well-known perfusion tracer CuPTSM, labelled with 62Cu or 64Cu, is believed to be trapped in cells non-selectively by a bioreductive mechanism. It is proposed that by modifying theExpand
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Maternal undernutrition alters triiodothyronine concentrations and pituitary response to GnRH in fetal sheep.
The aims of this study were to determine which hormones may have a role in the expression of maternal undernutrition effects on reproductive function, in both the developing fetus and the adultExpand
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Effects of maternal undernutrition during early pregnancy on apoptosis regulators in the ovine fetal ovary.
This study aimed to determine whether reduced fetal ovary folliculogenesis in ewes undernourished during early/midpregnancy is associated with altered ovarian cell proliferation and/or the expressionExpand
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