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Role of adenosine in sleep and temperature regulation in the preoptic area of rats
A site for the central hypnotic action ofadenosine, and a functional role for adenosine A1 receptors in the hypothalamus are demonstrated.
Adenosine analogs and sleep in rats.
- M. Radulovački, R. M. Virus, M. Djuricic-Nedelson, R. Green
- Chemistry, MedicineThe Journal of pharmacology and experimental…
- 1 February 1984
The results indicate that the effect on sleep of all three adenosine analogs was obtained with nanomolar doses of the drugs and that it diminished or disappeared when the drug dose reached micromolar range (0.9 mumol/kg); it appears, therefore, that activation of A1 rather than A2 receptors contributed to the sleep effects of the Drugs.
Prenatal exposure to diazepam results in enduring reductions in brain receptors and deep slow wave sleep
These results provide first evidence for a physiological role for benzodiazepine receptors by showing that prenatal exposure to diazepam has an enduring and detrimental effect on their ontogenesis and sleep mechanisms.
Effects of diazepam on sleep, temperature, 5-hydroxyindoleacetic and homovanillic acids in cisternal cerebrospinal fluid of cats.
Lack of correlation between various doses of DZ, and 5-HIAA or HVA concentrations in the presence of an increased percentage of SWS suggests a possible mode of D Z action mediated through a mechanism independent of monoamines.
Effect of interhemispheric transection on the EEG patterns in sleep and wakefulness in monkeys.
- C. Batini, M. Radulovački, R. T. Kado, W. R. Adey
- Psychology, MedicineElectroencephalography and clinical…
- 1 February 1967
The role of the interhemispheric commissural pathways in the synchronization of cerebral electrical activity has been studied in Macaca nemestrina and similarity of patterns between hemispheres in short epochs appeared unaltered in the split brain animal.
THE HIPPOCAMPUS AND THE ORIENTING REFLEX.
It is concluded that within a single brain system, there is a clear capacity for participation in related but differing behavioral responses, with induction of greatly differing EEG patterns in discriminative and orienting responses.
Hypnotic effects of deoxycorformycin in rats
Rats implanted with EEG and EMG electrodes were treated with deoxycoformycin and results appear to be consistent with those reported previously for the adenosine analog, N6-(L-phenylisopropyl)-adenosine (L-PIA) and indicate a hypnotic role forAdenosine.
Role of adenosine in sleep in rats.
- M. Radulovački
- MedicineReviews in clinical & basic pharmacology
- 1 July 1985
REM sleep deprivation significantly increased the number of A1 receptors (Bmax) in cerebral cortex and corpus striatum which correlates with the increased pressure for REM sleep and the onset of REM sleep rebound, indicating a role for adenosine in the regulation of sleep and, in contrast to barbiturate and benzodiazepine hypnotics, increase in behaviorally deep and REM sleep.
Desensitization of adenosine A2 receptors in the striatum of the rat following chronic treatment with diazepam
- M. Hawkins, W. Pan, P. Stefanovich, M. Radulovački
- Medicine, ChemistryNeuropharmacology
- 1 November 1988
It is indicated that functional adenosine A2 receptors were desensitized after prolonged treatment with diazepam, since decreased agonist binding to A1 receptors paralleled an attenuation in the stimulation byadenosine of the activity of adenylate cyclase, an effect mediated by the A2 receptor.
Circadian variation of [3H]N6-(l-phenylisopropyl)adenosine binding in rat brain
Circadian variations of adenosine receptor binding were examined in whole rat brain using [3H]N6-(L-phenylisopropyl)adenosine and data indicate a daily rhythm in the number ofAdenosine receptors without a change in Kd and may support the hypothesized involvement of adenoine in the regulation of sleep in rats.