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The dose-response effects of caffeine on sleep in rats
Caffeine at doses of 0.125, 1.25, 12.5 and 25 mg/kg was administered to rats and the subsequent effects on the sleep-wake cycle were measured. The 12.5 and 25 mg/kg doses of caffeine increasedExpand
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Efficacy of mirtazapine in obstructive sleep apnea syndrome.
STUDY OBJECTIVES Decreased serotonergic facilitation of upper-airway motor neurons during sleep has been postulated as an important mechanism rendering the upper airway vulnerable to obstruction inExpand
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Role of adenosine in sleep and temperature regulation in the preoptic area of rats
We have examined the effects on sleep and brain temperature of bilateral microinjections of adenosine and adenosine analogs to the preoptic area (PO) of rats. Administration of adenosine (12.5Expand
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Low-Frequency Oscillations of Cortical Oxidative Metabolism in Waking and Sleep
To study the changes in cortical oxidative metabolism and blood volume during behavioral state transitions, we employed reflectance spectrophotometry of the cortical cytochrome c oxidase (cyt aa3)Expand
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Diazepam suppresses sleep apneas in rats.
To test the respiratory effects of benzodiazepines in an established animal model of central apnea, we administered nonhypnotic and hypnotic doses of diazepam to nine adult male Sprague-Dawley ratsExpand
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Adenosine analogs and sleep in rats.
The effects of N6-L-(phenylisopropyl)adenosine, cyclohexyladenosine and adenosine-5'-N-ethylcarboxamide on sleep were examined in rats. These effects consist of 1) increased slow-wave sleep2 from 6.6Expand
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Prenatal exposure to diazepam results in enduring reductions in brain receptors and deep slow wave sleep
After prenatal exposure to diazepam (Valium), mature rats at 4 months of age displayed slow wave sleep (SWS) electroencephalographic patterns indicating impaired synchronization and SWS mechanisms.Expand
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Respiratory pattern modulation by the pedunculopontine tegmental nucleus
This study demonstrates respiratory modulation caused by stimulation of the pedunculopontine tegmental nucleus (PPT), a structure not classically included in the pontine respiratory neuronal network.Expand
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Monoaminergic system lesions increase post-sigh respiratory pattern disturbance during sleep in rats
Monoamines are important regulators of behavioral state and respiratory pattern, and the impact of monoaminergic control during sleep is of particular interest for the stability of breathingExpand
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Modulation of reflex and sleep related apnea by pedunculopontine tegmental and intertrigeminal neurons
We describe and summarize here our recent findings about the role in respiration of two pontine structures that are not classically included in the pontine respiratory group: the pedunculopontineExpand
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