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Role of adenosine in sleep and temperature regulation in the preoptic area of rats

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Role of adenosine in sleep in rats.

  • M. Radulovački
  • Biology, Chemistry
    Reviews in clinical & basic pharmacology
  • 1 July 1985
REM sleep deprivation significantly increased the number of A1 receptors (Bmax) in cerebral cortex and corpus striatum which correlates with the increased pressure for REM sleep and the onset of REM sleep rebound, indicating a role for adenosine in the regulation of sleep and, in contrast to barbiturate and benzodiazepine hypnotics, increase in behaviorally deep and REM sleep.
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Adenosine analogs and sleep in rats.

The results indicate that the effect on sleep of all three adenosine analogs was obtained with nanomolar doses of the drugs and that it diminished or disappeared when the drug dose reached micromolar range (0.9 mumol/kg); it appears, therefore, that activation of A1 rather than A2 receptors contributed to the sleep effects of the Drugs.
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Prenatal exposure to diazepam results in enduring reductions in brain receptors and deep slow wave sleep

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Diazepam and midazolam increase light slow-wave sleep (SWS1) and decrease wakefulness in rats

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Effects of diazepam on sleep, temperature, 5-hydroxyindoleacetic and homovanillic acids in cisternal cerebrospinal fluid of cats.

Lack of correlation between various doses of DZ, and 5-HIAA or HVA concentrations in the presence of an increased percentage of SWS suggests a possible mode of D Z action mediated through a mechanism independent of monoamines.
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Effect of interhemispheric transection on the EEG patterns in sleep and wakefulness in monkeys.

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Hypnotic effects of deoxycorformycin in rats

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Effect of tryptophan on sleep in the rat

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Desensitization of adenosine A2 receptors in the striatum of the rat following chronic treatment with diazepam

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