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Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds
The major challenge of tissue engineering is directing the cells to establish the physiological structure and function of the tissue being replaced across different hierarchical scales. To engineerExpand
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  • Open Access
Challenges in cardiac tissue engineering.
Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelityExpand
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Electrical stimulation systems for cardiac tissue engineering
We describe a protocol for tissue engineering of synchronously contractile cardiac constructs by culturing cardiac cells with the application of pulsatile electrical fields designed to mimic thoseExpand
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Influence of substrate stiffness on the phenotype of heart cells
Adult cardiomyocytes (CM) retain little capacity to regenerate, which motivates efforts to engineer heart tissues that can emulate the functional and mechanical properties of native myocardium.Expand
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Medium perfusion enables engineering of compact and contractile cardiac tissue.
We hypothesized that functional constructs with physiological cell densities can be engineered in vitro by mimicking convective-diffusive oxygen transport normally present in vivo. To test thisExpand
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  • Open Access
Biowire: a new platform for maturation of human pluripotent stem cell derived cardiomyocytes
Directed differentiation protocols enable derivation of cardiomyocytes from human pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro. However, hPSC-derivedExpand
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Design and formulation of functional pluripotent stem cell-derived cardiac microtissues
Significance Robust and predictive in vitro models of human cardiac tissue function could have transformative impact on our ability to test new drugs and understand cardiac disease. DespiteExpand
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  • Open Access
Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue
For clinical utility, cardiac grafts should be thick and compact, and contain physiologic density of metabolically active, differentiated cells. This involves the need to control the levels ofExpand
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Scaffolds with covalently immobilized VEGF and Angiopoietin-1 for vascularization of engineered tissues.
The aim of this study was to engineer a biomaterial capable of supporting vascularization in vitro and in vivo. We covalently immobilized vascular endothelial growth factor (VEGF) and Angiopoietin-1Expand
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Vascular endothelial growth factor immobilized in collagen scaffold promotes penetration and proliferation of endothelial cells.
A key challenge in engineering functional tissues in vitro is the limited transport capacity of oxygen and nutrients into the tissue. Inducing vascularization within engineered tissues is a keyExpand
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  • Open Access