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PEG-uricase in the management of treatment-resistant gout and hyperuricemia.
Hyperuricemia results from an imbalance between the rates of production and excretion of uric acid. Longstanding hyperuricemia can lead to gout, which is characterized by the deposition of monosodiumExpand
Structure, dissociation, and proteolysis of mammalian steroid receptors. Multiplicity of glucocorticoid receptor forms and proteolytic enzymes in rat liver and kidney cytosols.
The forms of steroid receptors detected in mammalian tissue cytosols vary from a globular fragment, the mero-receptor, with a molecular weight (Mr) of approximately 23,000 to highly asymmetricExpand
Structure of mammalian steroid receptors: evolving concepts and methodological developments.
Despite much work and significant progress on the stabilization, purification, and structural analysis of steroid receptors extracted from mamm alian tissues, the native state still remains largelyExpand
[18] Physical-chemical analysis of steroid hormone receptors☆
Publisher Summary Definitive evaluation of the mass, chemical composition, and conformation of steroid hormone receptors and of the changes that may occur on interaction with the steroid, theExpand
Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates
Anti-PEG antibodies have been reported to mediate the accelerated clearance of PEG-conjugated proteins and liposomes, all of which contain methoxyPEG (mPEG). The goal of this research was to assessExpand
Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase.
Uricase-deficient mice develop uric acid nephropathy, with high mortality rates before weaning. Urate excretion was quantitated and renal function was better defined in this study, to facilitate theExpand
Progesterone-binding components of chick oviduct. I. Preliminary characterization of cytoplasmic components.
Abstract Induction of the synthesis of the specific protein avidin by a single administration of progesterone has been demonstrated previously in chicks in vivo and in tissue minces and monolayerExpand
Estrogen receptor cleavage and plasminogen activation by enzymes in human breast tumor cytosol.
Estrogen receptors in cytoplasmic extracts of breast tumors from more than 40 patients were separately analyzed by gel filtration and/or ultracentrifugation under diverse conditions. ResultantExpand
Progesterone "receptors" in the cytoplasm and nucleus of chick oviduct target tissue.
This report demonstrates that the chick oviduct, a specific target organ for progesterone, contains both cytoplasmic and nuclear macromolecules which bind progestins. These binding molecules can beExpand