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A Phylogenetically Conserved Stem-Loop Structure at the 5′ Border of the Internal Ribosome Entry Site of Hepatitis C Virus Is Required for Cap-Independent Viral Translation
ABSTRACT Hepatitis C virus (HCV) initiates translation of its polyprotein under the control of an internal ribosome entry site (IRES) that comprises most of the 341-nucleotide (nt) 5′ nontranslated… Expand
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.
BACKGROUND & AIMS The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS Transgenic… Expand
Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of Viperin
- K. Helbig, J. Carr, +7 authors M. R. Beard
- Medicine, Biology
- PLoS neglected tropical diseases
- 1 April 2013
The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections. In this study we have shown that dengue virus type-2 (DENV-2) infection… Expand
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Macrophages are key target cells for HIV-1. HIV-1(BaL) induced a subset of interferon-stimulated genes in monocyte-derived macrophages (MDMs), which differed from that in monocyte-derived dendritic… Expand
Identification and characterization of a hepatitis delta virus RNA transcriptional promoter.
Transcription and replication of hepatitis delta virus (HDV) RNA are performed by the cellular enzyme RNA polymerase II (Pol II). As DNA is the normal template for Pol II, the enzyme must undergo… Expand
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector
- K. Helbig, D. T. Lau, L. Semendric, H. Harley, M. R. Beard
- Biology, Medicine
- 1 September 2005
Interferon (IFN) α inhibits hepatitis C virus (HCV) replication both clinically and in vitro; however, the complete spectrum of interferon‐stimulated genes (ISGs) expressed in the HCV‐infected liver… Expand
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A
The interferon‐stimulated gene, viperin, has been shown to have antiviral activity against hepatitis C virus (HCV) in the context of the HCV replicon, although the molecular mechanisms responsible… Expand
Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees
ABSTRACT Hepatitis C virus (HCV) infections represent a global health problem and are a major contributor to end-stage liver disease including cirrhosis and hepatocellular carcinoma. An improved… Expand
The role of viperin in the innate antiviral response.
Viral infection of the cell is able to initiate a signaling cascade of events that ultimately attempts to limit viral replication and prevent escalating infection through expression of host antiviral… Expand
Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.
BACKGROUND & AIMS Alcohol consumption exacerbates liver injury in chronic hepatitis C, and enhanced mitochondrial oxidative stress is one possible mechanism. The aim of this study was to determine… Expand