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Salvipisone and aethiopinone from Salvia sclarea hairy roots modulate staphylococcal antibiotic resistance and express anti-biofilm activity.
TLDR
It was concluded that salvipisone and aethiopinone synergized the action of beta-lactam antibiotics towards MRSA and MRSE probably by alteration of cell surface hydrophobicity and cell wall/membrane permeability, but not by changing penicillin-binding protein, PBP2a expression andpenicillinase production or by direct binding to the cell wall peptidoglycan and teichoic acids.
Co(II), Ni(II) and Cu(II) complexes with phenylthiazole and thiosemicarbazone-derived ligands: synthesis, structure and cytotoxic effects
Complexes of Co(II), Ni(II) and Cu(II) with 2-(3,5-dimethyl-1H-pyrazole-1-yl)-4-phenyl-1,3-thiazole (a) and 3,5-dimethyl-1H-pyrazole-1-carbothioamide (b) ligands were synthesized. The crystal and
Chemical Composition and Biological Activities of Essential Oil from Salvia sclarea Plants Regenerated in vitro
TLDR
The essential oils obtained by hydrodistillation of dried aerial parts of Salvia sclarea L. plants, regenerated in vitro and reproduced from seeds, were analyzed by GC and GC-MS and showed antimicrobial and cytotoxic activity.
Cytotoxic and Proapoptotic Activity of Diterpenoids from in vitro Cultivated Salvia sclarea Roots. Studies on the Leukemia Cell Lines
TLDR
The results obtained in this study show that S. sclarea diterpenoids aethiopinone and salvipisone may be useful in the treatment of human cancers, especially in the case of drug resistance.
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