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Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O2− and Systolic Blood Pressure in Mice
TLDR
The hypothesis that inhibition of the interaction of p47phox and gp91phox (or its homologues) can block O2− production and attenuate blood pressure elevation in mice is supported. Expand
Botanical polysaccharides: macrophage immunomodulation and therapeutic potential.
TLDR
The evaluation of botanical polysaccharide isolated from a wide array of different species of flora provides a unique opportunity for the discovery of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties. Expand
Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases
TLDR
Key structural and functional features of the neutrophil NADPH oxidase and its protein components are described, including a consideration of transcriptional and post‐translational regulatory features. Expand
Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis.
TLDR
Sponge implant assays demonstrate that VEGF-, but not S1P-, induced angiogenesis is significantly reduced in wild-type mice treated with NAC and in gp91(phox-/-) mice, suggesting that ROS derived from gp91 (phox)-containing NAD(P)H oxidase play an important role inAngiogenesis in vivo. Expand
Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
TLDR
Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary Atherosclerotic disease. Expand
Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries: Regulation by Angiotensin II
TLDR
The results suggest that HVSMCs possess a functionally active gp91phox-containing neutrophil-like NAD(P)H oxidase, which is regulated by angiotensin II by inducing phosphorylation of p47phox, translocation of cytosolic subunits, and de novo protein synthesis. Expand
PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62.
TLDR
The crystal structure of the p40(phox)/p67(Phox) PB1 heterodimer is determined, which reveals that both domains have a beta grasp topology and that they bind in a front-to-back arrangement through conserved electrostatic interactions between an acidic OPCA motif on p40 (phox) and basic residues in p67( phox). Expand
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
TLDR
The differential roles of Nox1 and Nox4 in VSMC may be correlated with their differential compartmentalization in specific signaling domains in the membrane and focal adhesions. Expand
Aldosterone-induced inflammation in the rat heart : role of oxidative stress.
TLDR
Chronic ALDO/salt treatment is accompanied by a time-dependent sustained activation of NADPH oxidase with 3-nitrotyrosine generation and nuclear factor-kappaB activation expressed by endothelial cells and inflammatory cells, leading to a proinflammatory/fibrogenic phenotype involving vascular and nonvascular sites of injury found, respectively, in both normotensive and hypertensive right and left ventricles. Expand
Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins
TLDR
The key features of each NADPH oxidase protein are described and the current understanding of the specific molecular interactions occurring between these proteins are summarized, focusing on the role these protein:protein binding interactions play in the NADPH oxidation assembly process. Expand
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