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A NIR fluorescent probe for the detection and visualization of hydrogen sulfide using the aldehyde group assisted thiolysis of dinitrophenyl ether strategy.
- M. Qian, Liuwei Zhang, Xiaojun Peng
- Chemistry, BiologyJournal of materials chemistry. B
- 5 December 2018
A novel NIR fluorescent probe NDCM-2 based on the dicyanoisophorone derivative was designed and synthesized by employing ortho-aldehyde assisted thiolysis of 2,4-dinitrophenyl (DNP) ether as the sensing strategy to achieve highly specific H2S detection in living systems.
Ammonia elimination from protonated nucleobases and related synthetic substrates
Specific light-up pullulan-based nanoparticles with reduction-triggered emission and activatable photoactivity for the imaging and photodynamic killing of cancer cells.
A mitochondria-targeting and polarity-sensitive fluorescent probe for cancer diagnosis
Synthetic infrared nano-photosensitizers with hierarchical zoom-in target-delivery functionalities for precision photodynamic therapy.
Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy
In vivo studies revealed superior antitumor efficacy of tumor-targeted FPDP/DOX/shBeclin1 in comparison with non-FR- targeted PDP micelles and free DOX, highlighting the potential to overcome the limitations of DOX in clinical cancer therapy.
Progress in Research of Photo-controlled Drug Delivery Systems
Rationally modifying the dicyanoisophorone fluorophore for sensing cysteine in living cells and mice
A red-emitting fluorescent probe with large Stokes shift for real-time tracking of cysteine over glutathione and homocysteine in living cells.