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Gender differences in the levels of bisphenol A metabolites in urine.
The metabolism of bisphenol A (BPA), a suspected endocrine disruptor, should be considered for monitoring human exposure to BPA, because the conjugation with beta-D-glucuronide and sulfate reduces
Comparative estrogenic effects of p-nonylphenol by 3-day uterotrophic assay and female pubertal onset assay.
The data demonstrate that p-NP can accelerate the onset of puberty and alter estrous cyclicity in prepubertal female rats at oral doses lower than the subcutaneous doses typically used in the uterotrophic assay, suggesting that the female pubertal onset assay may be used as a sensitive testing method to detect environmental agents with weak estrogenic activity, but requires further research.
Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway.
It is suggested that the inhibition of pterostilbene to the cell proliferation and DNA synthesis of PDGF-BB-stimulated VSMCs may be mediated by the suppression of Akt kinase, and may be a potential anti-proliferative agent for the treatment of atherosclerosis and angioplasty restenosis.
Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation.
Results indicate that three of these beta-carboline alkaloids can selectively affect collagen-induced platelet aggregation with different potencies, and harmane and harmine were most potent, and their antiplatelet activities may be mediated by inhibiting PLCgamma2 and protein tyrosine phosphorylation with sequential suppression of cytosolic calcium mobilization and arachidonic acid liberation.
Bisphenol A-induced downregulation of murine macrophage activities in vitro and ex vivo.
In vitro, BPA suppressed TNF-α secretion with significant reduction at 10 and 100μM BPA, and similar findings were observed with the macrophages from the BPA-exposed mice.
Antithrombotic and antiplatelet activities of fenofibrate, a lipid-lowering drug.
It is demonstrated that fenofibrate can significantly inhibit artery thrombus formation in vivo, which may be due to antiplatelet activity via the inhibition of thromboxane A(2) receptor, cytosolic calcium mobilization and COX-1 activity, and the beneficial effect of fen ofibrate on cardiovascular system may be also due to its modulation of platelet activation.
Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine
It is suggested that DA-9701 might affect gastrointestinal motility by the modulation of pacemaker activity in the ICC, and the activation is associated with the non-selective cationic channels via external Ca2+ influx, phospholipase C activation, andCa2+ release from internal storage in a G protein-independent and protein kinase C-independent manner.
Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice.
It is suggested that IO modulates immune responses through secretion of Th1/Th2 cytokines in immune cells and regulates antigen-specific antibody production.
Influence of melatonin on immunotoxicity of lead.
  • Y. Kim, M. Pyo, J. Kim
  • Biology, Medicine
    International journal of immunopharmacology
  • 1 October 2000
The results suggested that immunotoxicity induced by lead was significantly restored or prevented by melatonin (MLT), as well as the natural killer cell, phagocytic activity and the number of peripheral leukocytes were significantly enhanced in Pb plus MLT-treated mice.
Proteomic biomarkers for prenatal bisphenol A—Exposure in mouse immune organs
This study, which is based on proteome analyses, suggests that apo‐AI, DPPIII, and VAT represent protein biomarkers for BPA and provide useful mechanistic clues for B PA‐induced endocrine disruption.