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Linkage disequilibrium in humans: models and data.
In this review, we describe recent empirical and theoretical work on the extent of linkage disequilibrium (LD) in the human genome, comparing the predictions of simple population-genetic models toExpand
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Molecular evolution of FOXP2, a gene involved in speech and language
Language is a uniquely human trait likely to have been a prerequisite for the development of human culture. The ability to develop articulate speech relies on capabilities, such as fine control ofExpand
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The signature of positive selection at randomly chosen loci.
In Drosophila and humans, there are accumulating examples of loci with a significant excess of high-frequency-derived alleles or high levels of linkage disequilibrium, relative to a neutral model ofExpand
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A new approach to estimate parameters of speciation models with application to apes.
How populations diverge and give rise to distinct species remains a fundamental question in evolutionary biology, with important implications for a wide range of fields, from conservation genetics toExpand
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Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?
With the recent revolution in sequencing, we revisit the unresolved question of what influences the range and values of genetic diversity across taxa.
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Pervasive Natural Selection in the Drosophila Genome?
Over the past four decades, the predominant view of molecular evolution saw little connection between natural selection and genome evolution, assuming that the functionally constrained fraction ofExpand
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Adjusting the focus on human variation.
Studies of nuclear sequence variation are accumulating, such that we can expect a good description of the structure of human variation across populations and genomic regions in the near future. ThisExpand
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Determinants of mutation rate variation in the human germline.
Because germline mutations are the source of all evolutionary adaptations and heritable diseases, characterizing their properties and the rate at which they arise across individuals is of fundamentalExpand
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Genetic Structure of Chimpanzee Populations
Little is known about the history and population structure of our closest living relatives, the chimpanzees, in part because of an extremely poor fossil record. To address this, we report the largestExpand
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A neutral explanation for the correlation of diversity with recombination rates in humans.
One of the most striking findings to emerge from the study of genomic patterns of variation is that regions with lower recombination rates tend to have lower levels of intraspecific diversity but notExpand
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