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Toward the Definition of the Mechanism of Action of Silymarin: Activities Related to Cellular Protection From Toxic Damage Induced by Chemotherapy
TLDR
The protective effects of silymarin and silibinin, demonstrated in various tissues, suggest a clinical application in cancer patients as an adjunct to established therapies, to prevent or reduce their toxicity.
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Changes in vessel ultrastructure during ischemia and reperfusion of rabbit hindlimb: implications for therapeutic intervention.
TLDR
Several different cell types are involved in the pathophysiological changes which occur in microvessels during ischemia/reperfusion injury, and Pharmacological interventions, which inhibit the interactions of blood cells with endothelium, may be of value in the treatment of peripheral ischemian injury.
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Platelet activating factor induces dopamine release in PC-12 cell line.
The ability of platelet activating factor (PAF) to stimulate dopamine release and modify calcium homeostasis in PC-12 cell line was studied. PAF-induced dopamine release is related to its molecular…
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Aescin protection of human vascular endothelial cells exposed to cobalt chloride mimicked hypoxia and inflammatory stimuli.
TLDR
Pre-treatment of HUVECs with aescin prevented, in a concentration-dependent fashion, the action of CoCl2 on VCAM-1 and PECam-1, also preserving endothelial cell morphology, and reduced IL-6 release from LPS-activated vascular endothelium.
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Endothelium as a therapeutical target in peripheral occlusive arterial diseases: consideration for pharmacological interventions.
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Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats.
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Effect of Cloricromene During Ischemia and Reperfusion of Rabbit Hindlimb: Evidence for an Involvement of Leukocytes in Reperfusion-Mediated Tissue and Vascular Injury
TLDR
The results suggest that leukocytes can play a key role in the genesis of ischemia/reperfusion-related tissue injury and may suggest that inhibition of leukocyte functions may be useful in therapy of peripheral vascular disease.
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Effects of long-term diabetes and treatment with gangliosides on cardiac sympathetic innervation: a biochemical and functional study in mice.
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Functional Depression of Isolated Perfused Rat Heart Mediated by Activated Leukocytes: Protective Effect of Cloricromene
TLDR
A role of leukocyte activation in the genesis of heart damage is suggested and the possibility of a pharmacologic intervention with drugs such as CLO that can interfere with this process is raised.
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Effects of electromagnetic fields of low frequency and low intensity on rat metabolism
TLDR
The evidence that long term exposure to electromagnetic fields with a well defined frequency may have relevant effects on parameters such as body weight, blood glucose and fatty acid metabolism has been obtained.
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