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RNA recognition by a Staufen double‐stranded RNA‐binding domain
It is shown that the RNA‐binding activity of dsRBD3 is required in vivo for Staufen‐dependent localization of bicoid and oskar mRNAs.
The Solution Structure of the S1 RNA Binding Domain: A Member of an Ancient Nucleic Acid–Binding Fold
Thermodynamic stability of wild-type and mutant p53 core domain.
- A. Bullock, J. Henckel, A. Fersht
- BiologyProceedings of the National Academy of Sciences…
- 23 December 1997
A system is set up to analyze the stability of the core domain of the tumor suppressor p53 and its mutants and the possibility of rescue and there are excellent two-state denaturation curves on the addition of urea that may be analyzed quantitatively.
NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N‐terminal domain of ribosomal protein S5.
- M. Bycroft, S. Grünert, A. Murzin, M. Proctor, D. St Johnston
- Biology, ChemistryThe EMBO journal
- 1 July 1995
Using in vitro mutagenesis, several surface residues which are important for the RNA binding of the dsRBD, and these all lie on the same side of the domain, suggesting that the two domains interact with RNA in a similar way.
Hot-spot mutants of p53 core domain evince characteristic local structural changes.
- K. B. Wong, B. DeDecker, S. Freund, M. Proctor, M. Bycroft, A. Fersht
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 July 1999
Comparisons of wild-type and mutant p53 core domains in solution by NMR spectroscopy show that R248Q, which is often regarded as a contact mutant that affects only interactions with DNA, introduces structural changes as extensive as the other loop L3 mutations (G245S and R249S).
The UBX domain: a widespread ubiquitin-like module.
The three-dimensional structure of the UBX domain of human Fas-associated factor-1 (FAF1) by NMR spectroscopy is solved, suggesting that the two structures share the same superfold, and an evolutionary relationship.
Diagnosis and management of deformational plagiocephaly.
Recommendations are that more parental education is needed to minimize the development and progression of deformational plagiocephaly and the available data do not support the need for FDA classification for cranial orthoses as Class II devices requiring premarket notification.
Efficacy of Tranexamic Acid in Pediatric Craniosynostosis Surgery: A Double-blind, Placebo-controlled Trial
TXA is effective in reducing perioperative blood loss and transfusion requirement in children undergoing craniosynostosis reconstruction surgery.
The presentation and management of nasal dermoid: a 30-year experience.
Nasal dermoid is a rare congenital anomaly and preoperative evaluation is essential to rule out intracranial extension, and surgical strategy depends on the location and extent of the lesion, ranging from local excision to a combined intrac Craniofacial-extracranial approach.
The management of sagittal synostosis using endoscopic suturectomy and postoperative helmet therapy.
- E. Ridgway, J. Berry-Candelario, R. Grondin, G. Rogers, M. Proctor
- MedicineJournal of neurosurgery. Pediatrics
- 1 June 2011
Sagittal synostosis can be safely treated with endoscopic suturectomy and helmet therapy and improvements in cranial volume and shape are comparable to open procedures and are enduring.