Share This Author
The core meiotic transcriptome in budding yeasts
High-density oligonucleotide microarrays were used to analyse the genomes and meiotic expression patterns of two yeast strains that display distinct kinetics and efficiencies of sporulation and yielded approximately 1,600 meiotically regulated genes in each strain.
The BioMart community portal: an innovative alternative to large, centralized data repositories
The latest version of the BioMart Community Portal comes with many new databases that have been created by the ever-growing community and comes with better support and extensibility for data analysis and visualization tools.
The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle Cells
- M. Kitzmann, G. Carnac, M. Vandromme, M. Primig, N. Lamb, Anne Fernandez
- BiologyThe Journal of cell biology
- 21 September 1998
It is demonstrated that the two myogenic factors MyoD and Myf-5 undergo specific and distinct cell cycle-dependent regulation, thus establishing a correlation between the cell cycle–specific ratios of Myo D and My f-5 and the capacity of cells to differentiate.
The conserved transcriptome in human and rodent male gametogenesis
Genes known to be important for sexual reproduction are significantly enriched among differentially expressed core loci and a smaller group of conserved genes not detected in 17 nontesticular somatic tissues, correlating transcriptional activation and essential function in the male germ line.
Reversible methylation and inactivation of marker genes in sequentially transformed tobacco plants
Surprisingly, both the methylation and inactivation of T‐DNA‐I genes occurred only in plants containing both T‐DNAs: when self‐fertilization or backcrossing produced progeny containing only T‐ DNA‐I, expression of the genes on this T-DNA was restored and the corresponding promoters were partially or completely demethylated.
Execution of the meiotic noncoding RNA expression program and the onset of gametogenesis in yeast require the conserved exosome subunit Rrp6
- A. Lardenois, Yuchen Liu, M. Primig
- BiologyProceedings of the National Academy of Sciences
- 13 December 2010
A unique function for budding yeast Rrp6 is demonstrated in degrading distinct classes of meiotically induced ncRNAs during vegetative growth and the onset of meiosis and thus points to a critical role of differential ncRNA expression in the execution of a conserved developmental program.
A screen for genes required for meiosis and spore formation based on whole-genome expression
RhoA GTPase and serum response factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts.
The results establish the first link between RhoA protein activity and the expression of a key muscle regulator, and illustrate that MyoD and Myf5 are regulated by different upstream activation pathways in which Myo D expression is specifically modulated by a Rho a/SRF signaling cascade.
The DNA binding and oligomerization domain of MCM1 is sufficient for its interaction with other regulatory proteins.
In vitro binding studies suggest that a region of approximately 50 amino acids of MCM1 is essential for providing contacts with alpha 1, alpha 2 and STE12, and it is shown that the amino‐terminal third of theMCM1 protein is sufficient for the physical interaction with these factors.