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The size and burden of mental disorders and other disorders of the brain in Europe 2010
TLDR
The true size and burden of disorders of the brain in the EU was significantly underestimated in the past, and Concerted priority action is needed at all levels, including substantially increased funding for basic, clinical and public health research and policy decisions.
Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study.
TLDR
The results suggest that sleep-disordered breathing is highly prevalent, with important public health outcomes, and that the definition of the disorder should be revised.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
TLDR
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
TLDR
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
Cost of disorders of the brain in Europe 2010
TLDR
The present report presents much improved cost estimates for the total cost of disorders of the brain in Europe in 2010, covering 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items.
A mega-analysis of genome-wide association studies for major depressive disorder
TLDR
Although this is the largest genome-wide analysis of MDD yet conducted, its high prevalence means that the sample is still underpowered to detect genetic effects typical for complex traits, and it was unable to identify robust and replicable findings.
Meta-analysis and imputation refines the association of 15q25 with smoking quantity
TLDR
TheOx-GSK study established to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits confirmed an effect on smoking quantity at a locus on 15q25 that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits.
Familial transmission of substance use disorders.
TLDR
Elevation in risk of drug disorders among the relatives of probands with drug disorders across a wide range of specific substances, including opioids, cocaine, cannabis, and alcohol, which is largely independent from the familial aggregation of both alcoholism and antisocial personality disorder.
Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version
TLDR
The semi-structured Diagnostic Interview for Genetic Studies appears to be a useful part of data collection for genetic studies on major mood disorders and schizophrenia in French-speaking populations.
Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts
TLDR
The results from this study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in the authors' datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays.
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