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LCZ696: a dual-acting sodium supramolecular complex
LCZ696 displays several surprising features, such as an intrinsic stabilization of the supramolecular complex by monovalent multi-coordinated sodium cations and water molecules. In addition, to theExpand
Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 2: Synthesis of Fragments C1-6 and C9-14
Kilogram-scale syntheses of fragments C1-6 (6) and C9-14 (4) of (+)-discodermolide from common precursor 3 are described. Improved procedures for each step of both fragments were developed byExpand
Phosphinato(dialkylmethyl)phosphonates as pyrophosphate mimics: synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates
Abstract The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described. The phosphinato(dimethylmethyl)phosphonate group provided aExpand
A new, economical, practical and racemization-free method for the reductive removal of 2-oxazolidinones from N-acyloxazolidinones with sodium borohydride
Abstract A new, economical, practical and racemization-free method for the reductive removal of 2-oxazolidinones by a reduction of N-acyloxazolidinones with sodium borohydride in THF and water isExpand
An efficient large scale resolution of (±)-threo-methylphenidate hydrochloride (Ritalin® hydrochloride)
Abstract An efficient and large scale preparation of (2 R ,2′ R )-(+)- threo -methylphenidate hydrochloride ( 3 ) by the resolution of (±)- threo -methylphenidate hydrochloride ( 1 ) salt with O , OExpand
An unexpected reaction of arenesulfonyl cyanides with allylic alcohols: preparation of trisubstituted allyl sulfones.
TLDR
It is significant that a new method to synthesize sulfinates of the type 1 is unprecedented, quite general, and proceeds efficiently at ambient temperature. Expand
A Practical and Chemoselective Reduction of Nitroarenes to Anilines Using Activated Iron
Reduction of nitroarenes to anilines using activated iron generated by Fe/HCl or Zn/FeSO 4 is described. A variety of functional groups such as alkyne, ketone, enone, nitrile, lactone, and aromaticExpand
Palladium-catalyzed amination of aryl bromides with hindered N-alkyl-substituted anilines using a palladium(I) tri-tert-butylphosphine bromide dimer.
An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)(2) and P(t-Bu)(3) or a palladium(I)Expand
A facile asymmetric synthesis of either enantiomer of 2-substituted pyrrolidines.
TLDR
A new and general method for asymmetric synthesis of either enantiomer of 2-substituted pyrrolidines from a single starting material is described and was found to be effective for a variety of substrates including aromatic, heteroaromatic, and aliphatic substituents. Expand
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