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An open-label trial in Friedreich ataxia suggests clinical benefit with high-dose resveratrol, without effect on frataxin levels
Friedreich ataxia (FRDA) is due to a triplet repeat expansion in FXN, resulting in deficiency of the mitochondrial protein frataxin. Resveratrol is a naturally occurring polyphenol, identified toExpand
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Hydrogen sulphide induces HIF-1α and Nrf2 in THP-1 macrophages.
The transcription factor HIF-1α regulates the adaptive response of cells to hypoxia and oxidative stress. In addition, an important regulatory role for HIF-1α in immune reactions and inflammation isExpand
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The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation
Abstract Uremic toxins have been shown to play a role in chronic kidney disease (CKD) associated oxidative stress. Oxidative stress and inflammation have been associated with increased risk ofExpand
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Carbamoylation abrogates the antioxidant potential of hydrogen sulfide.
Hydrogen sulfide (H2S) has been identified as the third gasotransmitter. Beside its role as signaling molecule in the cardiovascular and nervous system the antioxidant and cyto-protective propertiesExpand
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Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
This study identifies BNIP3L as the key regulator of p53-dependent cell death mechanism in colon cancer cells targeted by the novel gallium based anticancer drug, KP46. KP46 specifically accumulatedExpand
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The uremic toxin indoxyl sulfate acts as a pro- or antioxidant on LDL oxidation.
Uremic toxins have been shown to play a role in chronic kidney disease (CKD) associated oxidative stress. Oxidative stress and inflammation have been associated with increased risk of cardiovascularExpand
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Iron sucrose and ferric carboxymaltose: no correlation between physicochemical stability and biological activity
Intravenous iron preparations, like iron sucrose (IS) and ferric carboxymaltose (FCM) differ in their physicochemical stability. Thus differences in storage and utilization can be expected and wereExpand
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Bioavailability and stability of intravenous iron sucrose originator versus generic iron sucrose AZAD
Abstract Context: Severe iron deficiency requires intravenous iron supplementation to replenish iron stores. Intravenous iron sucrose has been used for decades for the treatment of anemia. NewExpand
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Biochemical aspects to improve treatment of anemia in endstage renal disease and advanced biomarker assessment in iron related disorders
Storungen in der Eisen-Homoostase konnen zu schweren Erkrankungen fuhren. Beispielsweise ist die Anamie bei chronischer Niereninsuffizienz durch einen verringerten Eisenspiegel verursacht, wahrend esExpand