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Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
We have identified a significant source of low-frequency variation in blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) signal arising from spontaneous fluctuations in arterial carbon dioxide level in volunteers at rest. Expand
Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans.
This study examined the relationship between cerebral blood flow (CBF) and end-tidal PCO2 (PETCO2) in humans. We used transcranial Doppler ultrasound to determine middle cerebral artery peak blood… Expand
Dynamics of the cerebral blood flow response to step changes in end-tidal PCO2 and PO2 in humans.
This study examined the dynamics of the cerebral blood flow response to hypoxia and hypercapnia in humans. Middle cerebral artery blood flow (MCAF) was assessed continuously using transcranial… Expand
Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women
- A. D. Brown, C. McMorris, R. S. Longman, R. Leigh, M. Poulin
- Psychology, Medicine
- Neurobiology of Aging
- 1 December 2010
The mechanisms by which aerobic fitness confers beneficial effects on cognition with aging are unclear but may involve cerebrovascular adaptations. In a cross-sectional study of women from the… Expand
Cerebrovascular responses to altitude
- J. Brugniaux, A. N. Hodges, P. Hanly, M. Poulin
- Respiratory Physiology & Neurobiology
- 30 September 2007
The regulation of cerebral blood flow (CBF) is a complex process that is altered significantly with altitude exposure. Acute exposure produces a marked increase in CBF, in proportion to the severity… Expand
Intermittent Hypoxia Increases Arterial Blood Pressure in Humans Through a Renin-Angiotensin System–Dependent Mechanism
- G. Foster, P. Hanly, S. Ahmed, Andrew E Beaudin, V. Pialoux, M. Poulin
- 1 September 2010
Intermittent hypoxia (IH) is believed to contribute to the pathogenesis of hypertension in obstructive sleep apnea through mechanisms that include activation of the renin-angiotensin system. The… Expand
Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans
- P. Ainslie, Jon C. Ashmead, K. Ide, B. Morgan, M. Poulin
- The Journal of physiology
- 1 July 2005
The relative importance of CO2 and sympathetic stimulation in the regulation of cerebral and peripheral vasculatures has not been previously studied in humans. We investigated the effect of… Expand
Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans
- G. Mitsis, M. Poulin, P. Robbins, V. Marmarelis
- Materials Science, Computer Science
- IEEE Trans. Biomed. Eng.
- 18 October 2004
We show that cerebral autoregulation is strongly nonlinear and dynamic (frequency-dependent). Expand
Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans
Intermittent hypoxia (IH) is thought to be responsible for many of the long‐term cardiovascular consequences associated with obstructive sleep apnoea (OSA). Experimental human models of IH can aid in… Expand
Cerebrovascular Reserve: The Link Between Fitness and Cognitive Function?
- M. Davenport, D. Hogan, G. Eskes, R. S. Longman, M. Poulin
- Exercise and sport sciences reviews
- 1 April 2012
Better physical fitness in later life is associated positively with cognitive functioning. Novel data suggest that this association is mediated, in part, by increases in brain perfusion and the… Expand