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Comparative activity of pulsed or continuous estradiol exposure on gene expression and proliferation of normal and tumoral human breast cells.
It is shown that the genomic or proliferative effects of estradiol were identical with pulsed or continuous treatments, thus indicating that estrogenic effects are not strictly related to concentrations but rather to total hormone exposure. Expand
Plasma concentrations of ethynyl oestradiol and norethindrone after oral administration to women.
Plasma concentrations of ethynyl oestradiol and norethindrone in women were measured by radioimmunoassays after oral administration of 50 microngs and 1000 microng respectively and the calculated half-life was 6 1/2 h. Expand
Hormonal regulation of the androgen receptor expression in human prostatic cells in culture
It is demonstrated that prostate epithelial cells and fibroblasts have retained in culture, an hormonal sensitivity correlated with the presence of specific receptors and can serve as a model for the study of hormone action in this tissue in normal or pathological conditions. Expand
Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients.
Dihydrotestosterone (DHT), the 5 alpha-reduced metabolite of testosterone, is the active molecule triggering androgen action, and 5 alpha-reductase (5 alpha-R), the enzyme converting testosterone toExpand
Receptor and biological response to estriol in the fetal uterus of guinea pig.
It is concluded that estriol is capable of causing a biological response in the uterus during intra-uterine life and single daily injections of E3 to newborn guinea pig results only in weak uterotrophic activity. Expand
Photoaffinity labeling of the androgen receptor from human skin fibroblasts
The androgen receptor from human skin fibroblast can be efficiently photolabeled and could be used as a marker to follow receptor purification and the absence ofPhotolabeling of nuclear extracts from receptor-positive androgen-insensitive patients may reflect some abnormality of the receptor. Expand
Androgen insensitivity in oligospermic men: a reappraisal.
Androgen receptor BMAX levels were normal in all patients studied, regardless of the sperm density and the T X LH product, and infertility did not seem to be related to quantitative abnormality of the androgen receptor as was previously reported. Expand
A point mutation in the second zinc finger of the DNA-binding domain of the androgen receptor gene causes complete androgen insensitivity in two siblings with receptor-positive androgen resistance.
The mutation renders the AR nonfunctional and can, therefore, be held responsible for the clinical features in these patients, highlighting the importance of Arginine-614 in the second zinc finger of the DNA-binding domain of the AR in the protein-DNA interaction. Expand
Pharmacological and molecular evidence for the expression of the two steroid 5α‐reductase isozymes in normal and hyperplastic human prostatic cells in culture
Whereas the embryological development of the human prostate is clearly dependent on steroid 5α‐reductase (5α‐R) type 2 expression, the respective expression of the two known isoforms (types 1 and 2)Expand
Androgen dependence of the dunning R3327G cell line in monolayer culture
Evaluated the proliferative response of the Dunning R3327G tumor cell line (Du‐G cells) to 5α‐dihydrotestosterone (DHT) in monolayer culture to study the biochemical mechanisms mediating hormonal stimulation of cell proliferation. Expand