• Publications
  • Influence
The DNA/RNA-Dependent RNA Polymerase QDE-1 Generates Aberrant RNA and dsRNA for RNAi in a Process Requiring Replication Protein A and a DNA Helicase
The Neurospora RNA-dependent RNA polymerase QDE-1 is an RNA polymerase that can use both RNA and DNA as templates, suggesting a new mechanism for small RNA production.
  • 70
  • 11
  • PDF
Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes
Electron cryomicroscopy can yield near-atomic resolution structures of highly ordered macromolecular complexes. Often however some subunits bind in a flexible manner, have different symmetry from theExpand
  • 139
  • 8
  • PDF
Global Changes in Cellular Gene Expression during Bacteriophage PRD1 Infection
ABSTRACT Virus-induced changes in cellular gene expression and host physiology have been studied extensively. Still, there are only a few analyses covering the entire viral replication cycle andExpand
  • 69
  • 8
  • PDF
Self-assembly of a viral molecular machine from purified protein and RNA constituents.
We present the assembly of the polymerase complex (procapsid) of a dsRNA virus from purified recombinant proteins. This molecular machine packages and replicates viral ssRNA genomic precursors inExpand
  • 94
  • 7
Common principles in viral entry.
Viruses occur throughout the biosphere. Cells of Eukarya, Bacteria, and Archaea are infected by a variety of viruses that considerably outnumber the host cells. Although viruses have adapted toExpand
  • 106
  • 7
Incoming Influenza A Virus Evades Early Host Recognition, while Influenza B Virus Induces Interferon Expression Directly upon Entry
ABSTRACT The activation of the interferon (IFN) system, which is triggered largely by the recognition of viral nucleic acids, is one of the most important host defense reactions against viralExpand
  • 49
  • 5
Elongation-Competent Pauses Govern the Fidelity of a Viral RNA-Dependent RNA Polymerase.
RNA viruses have specific mutation rates that balance the conflicting needs of an evolutionary response to host antiviral defenses and avoidance of the error catastrophe. While most mutations areExpand
  • 51
  • 5
Roles of the minor capsid protein P7 in the assembly and replication of double-stranded RNA bacteriophage phi6.
The polymerase complexes of double-stranded RNA (dsRNA) viruses are multifunctional RNA processing machineries that carry out viral genome packaging, replication, and transcription. The polymeraseExpand
  • 20
  • 5
Innate Immune Responses in Human Monocyte-Derived Dendritic Cells Are Highly Dependent on the Size and the 5′ Phosphorylation of RNA Molecules
Recognition of viral genetic material takes place via several different receptor systems, such as retinoic acid-inducible gene I-like receptors and TLRs 3, 7, 8, and 9. At present, systematicExpand
  • 40
  • 4
Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee
This article is a summary of the activities of the ICTV's Bacterial and Archaeal Viruses Subcommittee for the years 2018 and 2019. Highlights include the creation of a new order, 10 families, 22Expand
  • 109
  • 3