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The DNA/RNA-Dependent RNA Polymerase QDE-1 Generates Aberrant RNA and dsRNA for RNAi in a Process Requiring Replication Protein A and a DNA Helicase
The Neurospora RNA-dependent RNA polymerase QDE-1 is an RNA polymerase that can use both RNA and DNA as templates, suggesting a new mechanism for small RNA production.
Common principles in viral entry.
Viruses encounter common problems during their entry process into the host cells, and similar strategies seem to ensure that the movement toward the site of replication and the translocation through the host membrane occur.
Global Changes in Cellular Gene Expression during Bacteriophage PRD1 Infection
- M. Poranen, J. Ravantti, A. Grahn, Rashi Gupta, P. Auvinen, D. Bamford
- Biology, MedicineJournal of Virology
- 15 August 2006
Changes in Escherichia coli gene expression during bacteriophage PRD1 infection using microarray technology are reported, indicating that there is no major reprogramming of the host during early infection.
Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes
- S. Ilca, A. Kotecha, Xiaoyu Sun, M. Poranen, D. Stuart, J. Huiskonen
- Biology, MedicineNature communications
- 4 November 2015
The method allows accurate fitting of the monomeric RNA-dependent RNA polymerase bound at the threefold axis of symmetry inside a viral capsid, revealing for the first time its exact orientation and interactions with the capsid proteins.
Self-assembly of a viral molecular machine from purified protein and RNA constituents.
This work demonstrates that this molecular machine, self-assembled under defined conditions in vitro, can function in its natural environment, the cell cytoplasm.
Incoming Influenza A Virus Evades Early Host Recognition, while Influenza B Virus Induces Interferon Expression Directly upon Entry
- P. Österlund, M. Strengell, +4 authors I. Julkunen
- Medicine, BiologyJournal of Virology
- 1 August 2012
Comparisons with type A and B influenza viruses in human dendritic cells provide new evidence of a novel antiviral evasion strategy for influenza A virus without a contribution of the viral NS1 protein, and opens up new insights into different influenza virus pathogenicities.
Roles of the minor capsid protein P7 in the assembly and replication of double-stranded RNA bacteriophage phi6.
- M. Poranen, S. Butcher, V. Simonov, P. Laurinmäki, D. Bamford
- Biology, MedicineJournal of molecular biology
- 14 November 2008
It is confirmed that full-length P7 is necessary for the formation of infectious viral particles using the in vitro assembly system for phi6 nucleocapsids and subsequent infectivity assays and found that P7 must be incorporated into polymerase complexes during shell assembly.
Innate Immune Responses in Human Monocyte-Derived Dendritic Cells Are Highly Dependent on the Size and the 5′ Phosphorylation of RNA Molecules
- M. Jiang, P. Österlund, +4 authors I. Julkunen
- Biology, MedicineThe Journal of Immunology
- 15 August 2011
The data suggest that human moDCs are extremely sensitive in recognizing foreign RNA, and the responses depend on RNA size, form (ssRNA versus dsRNA), and the level of 5′ phosphorylation, whereas ssRNA-induced responses were less dependent on the size of the RNA molecule.
Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee
- Evelien M. Adriaenssens, J. Wittmann, +28 authors J. Rodney Brister
- Biology, MedicineArchives of Virology
- 5 January 2016
Highlights include the creation of a new order, 10 families, 22 subfamilies, 424 genera and 964 species in the ICTV's Bacterial and Archaeal Viruses Subcommittee for the years 2018 and 2019.
Large-scale production of dsRNA and siRNA pools for RNA interference utilizing bacteriophage ϕ6 RNA-dependent RNA polymerase
Pools of small interfering RNAs (siRNAs) derived from dsRNA produced by two novel, flexible virus-based systems significantly decreased the expression of a transgene in HeLa cells and blocked endogenous pro-apoptotic BAX expression and subsequent cell death in cultured sympathetic neurons.