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- Publications
- Influence
Synthesis and TNF expression inhibitory properties of new thalidomide analogues derived via Heck cross coupling.
- S. G. Stewart, Daniel M. Spagnolo, M. Polomska, Melvin Sin, M. Karimi, L. Abraham
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 November 2007
A library of new thalidomide analogues containing an olefin functionality were synthesised using a Heck cross coupling reaction from their aryl halogenated precursor. All analogues were tested for… Expand
New thalidomide analogues derived through Sonogashira or Suzuki reactions and their TNF expression inhibition profiles.
- S. G. Stewart, C. Braun, Sze-Ling Ng, M. Polomska, M. Karimi, L. Abraham
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 January 2010
A library of new thalidomide C4/5 analogues containing either a phenyl or alkyne tether were synthesized using Sonogashira or Suzuki cross coupling reactions from their aryl halogenated precursors.… Expand
A concise synthesis of maleic anhydride and maleimide natural products found in Antrodia camphorata
- S. G. Stewart, M. Polomska, R. W. Lim
- Chemistry
- 26 March 2007
Abstract Recently, the natural products maleic anhydride 1 and maleimides 2 and 3 have been isolated from the mycelium of Antrodia Camphorata , each displaying activity in LLC cell lines. We describe… Expand
Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core.
- L. F. Tietze, S. G. Stewart, M. Polomska, Andrea Modi, A. Zeeck
- Chemistry, Medicine
- Chemistry
- 18 October 2004
A synthesis of the carbocyclic core associated with the new anticancer agent mensacarcin (1) is reported. The strategy involves the synthesis of several novel highly substituted aromatic compounds,… Expand
Rapid Evaluation of Antrodia camphorata Natural Products and Derivatives in Tumourigenic Liver Progenitor Cells with a Novel Cell Proliferation Assay
- S. G. Stewart, L. A. Ho, M. Polomska, Alexander T Percival, George C T Yeoh
- Biology, Medicine
- ChemMedChem
- 5 October 2009
We report the syntheses of five natural product maleimide and maleic anhydrides from the mushroom Antrodia camphorata. The ability of these compounds to affect proliferation in non‐tumourigenic and… Expand
Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue.
- S. G. Stewart, C. Braun, M. Polomska, M. Karimi, L. Abraham, K. Stubbs
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 21 September 2010
Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the… Expand
Intramolecular Heck Reactions for the Synthesis of the Novel Antibiotic Mensacarcin: Investigation of Catalytic, Electronic and Conjugative Effects in the Preparation of the Hexahydroanthracene Core
- L. F. Tietze, S. G. Stewart, M. Polomska
- Chemistry
- 1 May 2005
The intramolecular Heck reaction of the three complex diphenyl substrates rac-2, 5 and rac-6, containing substituents with different electronic and conjugative properties, were examined. The Pd… Expand
A Concise Synthesis of Maleic Anhydride and Maleimide Natural Products Found in Antrodia camphorata.
- S. G. Stewart, M. Polomska, R. W. Lim
- Chemistry
- 17 July 2007
Low-temperature behaviour of (NH4)4H2(SeO4)3 and (ND4)4D2(SeO4)3 superionic conductors
- A. Pawłowski, B. Hilczer, M. Polomska, A. Pietraszko
- Chemistry
- 1 December 2001
Abstract The structure of (NH 4 ) 4 H 2 (SeO 4 ) 3 and of its deuterated analogue was re-determined at room temperature and at ∼140 K. In the examined temperature range, the same centrosymmetric… Expand