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The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart
The results demonstrate that a tissue‐specific adaptation of the Bcl‐2/Bax ratio occurs with age and may directly influence the release of cytochrome c.
Apoptosis and aging: role of the mitochondria.
This review will discuss apoptosis in the context of normal aging of T cells, cardiac myocytes, skeletal muscle, and brain cortex, and particular attention is paid to the role of the mitochondria because they have been implicated as a major control center regulating apoptosis.
Dissecting the Axoneme Interactome
PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat.
Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells.
Analysis of the progeny plasmid has revealed that H-epsilondC strongly blocks DNA synthesis and markedly miscodes in both hosts, indicating that this endogenous DNA adduct is very genotoxic to both organisms.
Endogenous Lipid Hydroperoxide-mediated DNA-adduct Formation in Min Mice*
The endogenous formation of heptanone-etheno adducts in mammalian tissue DNA for the first time is detected using highly specific and sensitive methodology based on stable isotope dilution liquid chromatography/tandem mass spectrometry.
Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.
Analysis of the reaction between 2'-deoxycytidine and 4-oxo-2-nonenal by LC/MS and NMR spectroscopy revealed the presence of three major products (adducts A(1), A(2), and B; [M + H](+) = 364).