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The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart
- M. Pollack, S. Phaneuf, A. Dirks, C. Leeuwenburgh
- BiologyAnnals of the New York Academy of Sciences
- 1 April 2002
The results demonstrate that a tissue‐specific adaptation of the Bcl‐2/Bax ratio occurs with age and may directly influence the release of cytochrome c.
Apoptosis and aging: role of the mitochondria.
This review will discuss apoptosis in the context of normal aging of T cells, cardiac myocytes, skeletal muscle, and brain cortex, and particular attention is paid to the role of the mitochondria because they have been implicated as a major control center regulating apoptosis.
Dissecting the Axoneme Interactome
PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat.
Translesion DNA Synthesis across the heptanone--etheno-2'-deoxycytidine adduct in cells.
- M. Pollack, I. Yang, Hye-young H Kim, I. Blair, M. Moriya
- Biology, ChemistryChemical research in toxicology
- 14 July 2006
Analysis of the progeny plasmid has revealed that H-epsilondC strongly blocks DNA synthesis and markedly miscodes in both hosts, indicating that this endogenous DNA adduct is very genotoxic to both organisms.
Part X • Chapter 30 – Molecular mechanisms of oxidative stress in aging: free radicals, aging, antioxidants and disease
Endogenous Lipid Hydroperoxide-mediated DNA-adduct Formation in Min Mice*
- M. Williams, Seon-Hwa Lee, M. Pollack, I. Blair
- Chemistry, BiologyJournal of Biological Chemistry
- 14 April 2006
The endogenous formation of heptanone-etheno adducts in mammalian tissue DNA for the first time is detected using highly specific and sensitive methodology based on stable isotope dilution liquid chromatography/tandem mass spectrometry.
Dissociation of ribonucleic acid and protein synthesis in mammalian cells deprived of potassium.
Characterization of 2'-deoxycytidine adducts derived from 4-oxo-2-nonenal, a novel lipid peroxidation product.
- M. Pollack, T. Oe, Seon-Hwa Lee, M. S. Silva Elipe, B. Arison, I. Blair
- ChemistryChemical research in toxicology
- 14 June 2003
Analysis of the reaction between 2'-deoxycytidine and 4-oxo-2-nonenal by LC/MS and NMR spectroscopy revealed the presence of three major products (adducts A(1), A(2), and B; [M + H](+) = 364).