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Pentylenetetrazol-induced seizures in rats: an ontogenetic study
- L. Velíšek, H. Kubová, M. Pohl, L. Staňková, P. Mares̆, R. Schickerová
- Biology, PsychologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 1 November 1992
A quantitative description of motor seizures induced by pentylenetetrazol (PTZ, metrazol) was performed in 477 male albino rats of the Wistar strain 7 to 90 days old and major seizures were elicited regularly at all developmental stages studied.
Effects of flunarizine on Metrazol-induced seizures in developing rats
Low magnesium-induced epileptiform discharges in guinea pig hippocampal slices: depression by the organic calcium antagonist verapamil
Paired-pulse and frequency potentiation of cortical responses in developing rats
Low-magnesium-induced epileptiform activity in the human neocortex maintained in vitro: Suppression by the organic calcium antagonist verapamil
Effects of loreclezole on metrazol-induced phenomena in developing rats.
Major metrazol seizures were suppressed by loreclezole in a dose-dependent manner in all age-groups, except in the 7 day old group where outlined changes did not reach statistical significance.
Localization of the Origin of Self‐Sustained Afterdischarges (SSADs) in the Rat
It is suggested that the cortex is the decisive factor in the genesis of S + W rhythm, while the thalamus markedly influences the conditions of its formation.
Is the site of action of ethosuximide in the hindbrain?
The action of ethosuximide, valproate and clonazepam against pentylenetetrazol-induced epileptic EEG phenomena was studied in acute experiments in rats with intercollicular brainstem transection and the site of anticonvulsant action may be localized in hindbrain structures.
Influence of clonidine on metrazol-induced seizures in young rats.
Influence of phenytoin and valproate on thalamocortical evoked potentials and their paired-pulse potentiation.
Paired-pulse potentiation of thalamocortical phenomena cannot be put into connection with the generation of the spike-and-wave rhythm.