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Neurocognitive aspects of pain perception
The contribution of attention, expectation and reappraisal are discussed as three basic mechanisms that are important for the cognitive modulation of pain.
Differential coding of pain intensity in the human primary and secondary somatosensory cortex.
The activation pattern of SI suggests participation of SI in the discriminative perception of pain intensity and the all-or-none-like activation pattern in SII points against a significant contribution of SII to the sensory-discriminative aspects of pain perception.
Gamma Oscillations in Human Primary Somatosensory Cortex Reflect Pain Perception
It is shown that selective nociceptive stimuli induce gamma oscillations in primary somatosensory cortex that are particularly related to the subjective perception of pain, and this findings support the hypothesis that Gamma oscillations arerelated to the internal representation of behaviorally relevant stimuli that should receive preferred processing.
Neurophysiology and Functional Neuroanatomy of Pain Perception
The authors review the evidence on which the proposed relationship between cortical areas, pain-related neural activations, and components of pain perception is based.
The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil
Using sophisticated brain imaging techniques, the authors show that one’s expectation of the success of a pain treatment can markedly influence its effectiveness, and how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging.
Parallel activation of primary and secondary somatosensory cortices in human pain processing.
Preservation of direct access to SII underscores the relevance of this area in human pain processing, probably reflecting an important role of SII in nociceptive learning and memory.
Anterior Insula Integrates Information about Salience into Perceptual Decisions about Pain
Evidence is provided that the anterior insula and MCC as a “salience network” integrate information about the significance of an impending stimulation into perceptual decision-making in the context of pain.
Differential organization of touch and pain in human primary somatosensory cortex.
Generation of the single nociceptive response in area 1, whereas tactile stimuli activate sequentially peaking sources in areas 3b and 1 is suggested, which may reflect that pain perception rather requires reactions to and avoidance of harmful stimuli than sophisticated sensory capacities.
Cortical representation of first and second pain sensation in humans
Single painful stimuli evoke two successive and qualitatively distinct sensations referred to as first and second pain sensation. Peripherally, the neural basis of this phenomenon is a dual pathway
Decoding the perception of pain from fMRI using multivariate pattern analysis
The results demonstrate that the neural representation of (near-threshold) pain is spatially distributed and can be best described at an intermediate spatial scale and represents a step towards the goal of establishing an objective neuronal marker of pain perception.