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Cytotoxic Activity and Antioxidant Capacity of Purified Lichen Metabolites: An In Vitro Study
The purpose of this study was to investigate the effects of six lichen metabolites (diffractaic acid, lobaric acid, usnic acid, vicanicin, variolaric acid, protolichesterinic acid) on proliferation,Expand
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Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein.
With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of five lichen secondary metabolites theExpand
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Lichen metabolites prevent UV light and nitric oxide-mediated plasmid DNA damage and induce apoptosis in human melanoma cells.
In humans both UV-A and UV-B can cause gene mutations and suppress immunity, which leads to skin cancer, including melanoma. Inhibition of reactive oxygen species (ROS) and reactive nitrogen speciesExpand
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Tropane alkaloids from Schizanthus litoralis
Abstract Six new tropane alkaloids have been isolated from the leaves of the endemic Chilian plant Schizanthus litoralis (Solanaceae). The new structures include a new tropanol dimer of itaconic acidExpand
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Cytotoxic and Apoptotic Effects on Hepatocytes of Secondary Metabolites Obtained from Lichens
There are a large number of species of Antarctic lichens, and several studies describing the secondary metabolites present in these lichens, as well as the advances in understanding the chemistry ofExpand
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Antimicrobial and antibiofilm activity of secondary metabolites of lichens against methicillin-resistant Staphylococcus aureus strains from cystic fibrosis patients.
AIM Three secondary metabolites of lichens - usnic acid, atranorin and fumarprotocetraric acid - were evaluated for their in vitro antibacterial and antibiofilm activities against three strains eachExpand
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Se evaluo la actividad antifungica de 10 (diez) depsidonas y 5 (cinco) depsidos, como tambien la actividad antibacteriana de estos compuestos, tres depsidos adicionales y un diarileter, todos ellosExpand
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Diterpenoids from Calceolaria inamoena.
Four 9-epi-ent-labdanes were isolated from the aerial parts of Calceolaria inamoena. Their structures, 2beta-hydroxy-9-epi-ent-labda8(17)-13(E)dien-15-oic acid,Expand
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Pannarin inhibits cell growth and induces cell death in human prostate carcinoma DU-145 cells
In the course of our continuing search for new natural anticancer compounds for treatment and/or prevention of prostate cancer, our laboratory has focused its search on poorly investigated lichenExpand
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In vitro interaction of usnic acid in combination with antimicrobial agents against methicillin-resistant Staphylococcus aureus clinical isolates determined by FICI and ΔE model methods.
The in vitro antimicrobial activities of usnic acid were evaluated in combination with five therapeutically available antibiotics, using checkerboard microdilution assay against methicillin-resistantExpand
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