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Genomic analysis of immunity in a Urochordate and the emergence of the vertebrate immune system: “waiting for Godot”
Genome-wide sequence analysis in the invertebrate chordate, Ciona intestinalis, has provided a comprehensive picture of immune-related genes in an organism that occupies a key phylogenetic positionExpand
A molecular phylogeographic study based on DNA sequences from individual metacercariae of Paragonimus mexicanus from Guatemala and Ecuador
Abstract A molecular phylogeographic study of Paragonimus mexicanus collected from Guatemala and Ecuador was performed. Genomic DNA was extracted from individual metacercariae, and two gene regionsExpand
The Gut of Geographically Disparate Ciona intestinalis Harbors a Core Microbiota
It is now widely understood that all animals engage in complex interactions with bacteria (or microbes) throughout their various life stages. This ancient exchange can involve cooperation and hasExpand
CiC3-1a-Mediated Chemotaxis in the Deuterostome Invertebrate Ciona intestinalis (Urochordata) 1
Deuterostome invertebrates possess complement genes, and in limited instances complement-mediated functions have been reported in these organisms. However, the organization of the complementExpand
A role for variable region-containing chitin-binding proteins (VCBPs) in host gut–bacteria interactions
A number of different classes of molecules function as structural matrices for effecting innate and adaptive immunity. The most extensively characterized mediators of adaptive immunity are theExpand
Complement in urochordates: cloning and characterization of two C3-like genes in the ascidian Ciona intestinalis
The recent identification of complement components in deuterostome invertebrates has indicated the presence of a complement system operating via an alternative pathway in echinoderms and tunicatesExpand
Ancient origin of the complement system: emerging invertebrate models.
Identification and developmental expression of Ci-isl, a homologue of vertebrate islet genes, in the ascidian Ciona intestinalis
Here we describe the cloning and expression pattern of Ci-isl, a homologue of vertebrate genes, in the ascidian. Early in development, Ci-isl expression occurs in the primordia of palps and brainExpand
Gamete self‐discrimination in ascidians: A role for the follicle cells
Gamete self‐incompatibility in the hermaphrodite tunicate Ciona intestinalis is a useful system with which to study self‐nonself recognition. We have used in vitro fertilization of oocytes isolatedExpand