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Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
ObjectiveTo determine the incidence, cost, and outcome of severe sepsis in the United States. DesignObservational cohort study. SettingAll nonfederal hospitals (n = 847) in seven U.S. states.Expand
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Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure.
In mechanically ventilated patients with acute circulatory failure related to sepsis, we investigated whether the respiratory changes in arterial pressure could be related to the effects of volumeExpand
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Passive leg raising predicts fluid responsiveness in the critically ill*
Objective:Passive leg raising (PLR) represents a “self-volume challenge” that could predict fluid response and might be useful when the respiratory variation of stroke volume cannot be used for thatExpand
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Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality.
PURPOSE Cytokines have been associated with the development of sepsis and diffuse tissue injury following septic or endotoxic challenges in humans. Furthermore, relative organ-system dysfunction, notExpand
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The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory
The acute respiratory distress syndrome (ARDS) continues as a contributor to the morbidity and mortality of patients in intensive care units throughout the world, imparting tremendous human andExpand
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Patients’ recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit*
Objective To describe stressful experiences of adult patients who received mechanical ventilation for ≥48 hrs in an intensive care unit. Design Prospective cohort study. Setting Four intensive careExpand
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Clinical review: Update on hemodynamic monitoring - a consensus of 16
Hemodynamic monitoring plays a fundamental role in the management of acutely ill patients. With increased concerns about the use of invasive techniques, notably the pulmonary artery catheter, toExpand
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Strong ion gap: a methodology for exploring unexplained anions.
PURPOSE This paper describes the calculation of the strong ion gap (SIG), a physical chemical methodology similar to the anion gap (AG), as a measure of the anion/cation balance exclusive of sodium,Expand
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Clinical use of respiratory changes in arterial pulse pressure to monitor the hemodynamic effects of PEEP.
In ventilated patients with acute lung injury (ALI) we investigated whether respiratory changes in arterial pulse pressure (DeltaPP) could be related to the effects of PEEP and fluid loading (FL) onExpand
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Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.
BACKGROUND Severe sepsis is common and frequently fatal, and community-acquired pneumonia (CAP) is the leading cause. Although severe sepsis is often attributed to uncontrolled and unbalancedExpand
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