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Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
TLDR
Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages. Expand
Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure.
TLDR
It was concluded that in mechanically ventilated patients with acute circulatory failure related to sepsis, analysis of DeltaPp is a simple method for predicting and assessing the hemodynamic effects of VE, and that DeltaP p is a more reliable indicator of fluid responsiveness than DeltaPs. Expand
Passive leg raising predicts fluid responsiveness in the critically ill*
TLDR
The changes in aortic blood flow induced by PLR predict pre load responsiveness in ventilated patients, whereas with arrhythmias and spontaneous breathing activity, respiratory variations of arterial pulse pressure poorly predict preload responsiveness. Expand
Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality.
TLDR
TNF and IL-6 serum levels are higher in septic than in nonseptic shock, but the persistence of TNF andIL-6 in the serum rather than peak levels of cytokines predicts a poor outcome in patients with shock. Expand
The American-European Consensus Conference on ARDS, part 2: Ventilatory, pharmacologic, supportive therapy, study design strategies, and issues related to recovery and remodeling. Acute respiratory
TLDR
The American-European Consensus Committee on ARDS was formed to re-evaluate the standards for the ICU care of patients with acute lung injury (ALI), with regard to ventilatory strategies, the more promising pharmacologic agents, and the definition and quantification of pathologic features of ALI that require resolution. Expand
Patients’ recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit*
TLDR
Stressful experiences associated with the endotracheal tube were strongly associated with subjects’ experiencing spells of terror, feeling nervous when left alone, and poor sleeping patterns, which suggests the potential for improved symptom management, which could contribute to a less stressful intensive care unit stay and improved patient outcomes. Expand
Clinical review: Update on hemodynamic monitoring - a consensus of 16
TLDR
An objective review of the available monitoring systems, including their specific advantages and limitations, and highlighting some key principles underlying hemodynamic monitoring in critically ill patients are offered. Expand
Strong ion gap: a methodology for exploring unexplained anions.
TLDR
The SIG technique can detect unknown anions in a patient population known to have them and does not detect unknownAnions in healthy volunteers during exercise, which means the test is both sensitive and specific in characterizing metabolic acidosis. Expand
Quality-adjusted survival in the first year after the acute respiratory distress syndrome.
TLDR
It is concluded that ARDS developing in previously healthy patients is associated with poor quality-adjusted survival and these data are important for cost-effectiveness analyses and long-term care. Expand
Use of non-invasive NIRS during a vascular occlusion test to assess dynamic tissue O2 saturation response
TLDR
That StO2 and HbT recovery co-vary only in trauma patients suggests that pre-existing vasoconstriction was unmasked by the ischemic challenge consistent with increased sympathetic tone. Expand
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