• Publications
  • Influence
Different embryo-fetal toxicity effects for three VLA-4 antagonists.
  • F. Crofts, M. Pino, +8 authors R. Clark
  • Biology, Medicine
  • Birth defects research. Part B, Developmental and…
  • 1 April 2004
BACKGROUND VLA-4 (Very late antigen 4, integrin alpha4beta1) plays an important role in cell-cell interactions that are critical for development. Homozygous null knockouts of the alpha4 subunit ofExpand
Critical period for a teratogenic VLA-4 antagonist: Developmental effects and comparison of embryo drug concentrations of teratogenic and non-teratogenic VLA-4 antagonists.
BACKGROUND Integrins such as VLA-4 (Very late antigen 4, integrin alpha4beta1) play key roles in cell-cell interactions that are critical for development. Homozygous null knockouts of the VLA-4Expand
Soluble guanylyl cyclase α1 subunit is a key mediator of proliferation, survival, and migration in ECC-1 and HeLa cell lines
Soluble guanylyl cyclase (sGC) is a heterodimeric enzyme constituted by two subunits, α1 and β1. Previously we have shown that 17β-estradiol (E2) exerts opposite effects on these subunits byExpand
Tl(I) and Tl(III) alter the expression of EGF‐dependent signals and cyclins required for pheochromocytoma (PC12) cell‐cycle resumption and progression
The effects of thallium [Tl(I) and Tl(III)] on the PC12 cell cycle were evaluated without (EGF−) or with (EGF+) media supplementation with epidermal growth factor (EGF). The following markers ofExpand
Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis
We have reported recently that the proliferation of PC12 cells exposed to micromolar concentrations of Tl(I) or Tl(III) has different outcomes, depending on the absence (EGF− cells) or the presenceExpand
Soluble Guanylyl Cyclase Alpha1 Subunit: A New Marker for Estrogenicity of Endocrine Disruptor Compounds.
Endocrine disruptor compounds (EDCs) comprise naturally occurring and synthetic substances widely spread in the environment that adversely affect human and wildlife. Because of the increasing numberExpand