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Calcified nodules in retinal drusen are associated with disease progression in age-related macular degeneration
TLDR
It is demonstrated that progression to AMD was associated with increasing degeneration of the RPE overlying HIRD, and that using multimodal clinical imaging to determine the composition of macular calcifications may help to direct therapeutic strategies and outcome measures in AMD.
Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
TLDR
The data suggest that sub-RPE deposit formation is initiated, and probably regulated, by the RPE, as well as the loss of permeability of the Bruch's membrane and choriocapillaris complex associated with age and early AMD.
On the origin of proteins in human drusen: The meet, greet and stick hypothesis
Electron-microscopic findings after transmyocardial laser revascularization in an acute ischemic pig model.
Mineralisation within human tooth cementum identified by secondary ion mass spectrometry
TLDR
It is concluded that although ToF-SIMS analysis holds great promise for increasing the knowledge of cementum composition, far more caution is required by researchers linking observed lines in this tissue to underlying causal life history mechanisms and explanations.
Life history parameters in acellular extrinsic fiber cementum microstructure
TLDR
A new methodological approach for cementum research is proposed, Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS), to measure degree and distribution of mineralization of cementum growth layers, and shows that Tof- SIMS can significantly increase the authors' knowledge of cementu composition and is therefore a powerful new tool for life history researchers.
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