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HPLC chiral stationary phases containing macrocyclic antibiotics: practical aspects and recognition mechanism.
TLDR
Synthetic strategies for the Preparation of Glycopeptides Containing CSPs for HPLC and Vancomycin Analogs are outlined.
Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes.
Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time
“Quasi flexible” automatic docking processing for studying stereoselective recognition mechanisms, part 2: Prediction of ΔΔG of complexation and 1H‐NMR NOE correlation
TLDR
A remarkable correlation between the theoretical results and experimental data supports the validity of the computational approach and underline the importance of the conformational multiplicity in the definition of the macroscopic properties of the complex in solution.
A quasi-flexible automatic docking processing for studying stereoselective recognition mechanisms. Part I. Protocol validation
TLDR
A general computational protocol for the global molecular interaction evaluation (“Glob-MolInE”) is developed to efficiently explore the orientational and conformational space of flexible selectors and selectands used in modern chiral high-performance liquid chromatography (HPLC).
Synthesis of amino and ammonium resorcin[4]arenes as potential receptors
Starting from the tetrabromide 1A (cone conformation) a number of resorcin[4]arene derivatives ( 3A, 4A, 5A, 6A) containing an amino function in the side chains have been prepared. Preliminary
A chromatographic study on the retention behavior of the amylose tris(3-chloro-5-methylphenylcarbamate) chiral stationary phase under aqueous conditions.
TLDR
Retention was significantly affected by small percentages of trifluoroacetic acid or diethylamine additives incorporated in the mobile phase, while the action of acid additive was more pronounced in the hydrophilic interaction liquid chromatography region.
A “quasi‐flexible” automatic docking processing for studying stereoselective recognition mechanisms. Part I. Protocol validation
The main purpose of this work is the development and validation of a general scheme based on a systematic and automatic “quasi‐flexible” docking approach for studying stereoselective recognition
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