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Leptospira: the dawn of the molecular genetics era for an emerging zoonotic pathogen
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causativeExpand
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Diagnosis and epidemiology of leptospirosis.
Leptospirosis is a zoonosis found worldwide, the main reservoir of which is the rat. Human infection generally results from exposure to contaminated river or lake water or animals. Around 600 casesExpand
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Genome Sequence of the Saprophyte Leptospira biflexa Provides Insights into the Evolution of Leptospira and the Pathogenesis of Leptospirosis
Leptospira biflexa is a free-living saprophytic spirochete present in aquatic environments. We determined the genome sequence of L. biflexa, making it the first saprophytic Leptospira to beExpand
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Identification of Variable-Number Tandem-Repeat Loci in Leptospira interrogans Sensu Stricto
ABSTRACT Leptospira interrogans sensu stricto is responsible for the most frequent and severe cases of human leptospirosis. The epidemiology and clinical features of leptospirosis are usuallyExpand
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Application of Multilocus Variable-Number Tandem-Repeat Analysis for Molecular Typing of the Agent of Leptospirosis
ABSTRACT Leptospirosis is a worldwide-distributed zoonosis, endemic in tropical areas. Epidemiologic investigations of leptospirosis still rely on tedious serological identification tests. Recently,Expand
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A century of Leptospira strain typing.
Leptospirosis is a zoonotic disease with high mortality and morbidity rates in humans and animals throughout the world. Since the discovery of Leptospira, the causal agent of leptospirosis, a centuryExpand
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The OmpA-Like Protein Loa22 Is Essential for Leptospiral Virulence
Pathogenic mechanisms of Leptospira interrogans, the causal agent of leptospirosis, remain largely unknown. This is mainly due to the lack of tools for genetic manipulations of pathogenic species. InExpand
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Genotypic characterization of five subspecies of Mycobacterium kansasii.
Different molecular typing methods including restriction fragment length polymorphism (RFLP) analysis with the major polymorphic tandem repeat (MPTR) probe and the IS1652 probe, pulsed-field gelExpand
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Virulence of the zoonotic agent of leptospirosis: still terra incognita?
  • M. Picardeau
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 1 May 2017
Pathogenic leptospires are the bacterial agents of leptospirosis, which is an emerging zoonotic disease that affects animals and humans worldwide. The success of leptospires as pathogens is explainedExpand
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Rapid tests for diagnosis of leptospirosis: current tools and emerging technologies.
Leptospirosis is an emerging zoonosis with a worldwide distribution but is more commonly found in impoverished populations in developing countries and tropical regions with frequent flooding. TheExpand
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