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Chelators as antidotes of metal toxicity: therapeutic and experimental aspects.
It has been shown in experiments using young and adult animals that metal toxicity and chelation effects could be influenced by age, which may have a bearing in the design of new therapeutic chelation protocols for metal toxicity. Expand
Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats.
Acute Cd effects on steroidogenesis are most severe in rats evaluated in proestrus or in early pregnancy, while in late pregnancy steroidogenesis is relatively unaffected, and cadmium appears to interfere with normal steroidogenesis at a number of sites in the biosynthetic pathway. Expand
Metals in human placenta: focus on the effects of cadmium on steroid hormones and leptin
The results strongly suggest that cadmium may cause a decline in placental leptin synthesis, as it has been shown for placental progesterone production, and may constitute further evidence of the endocrine‐disrupting effects of Cadmium, as a constituent of tobacco smoke, on reproduction in women. Expand
Placental cadmium and progesterone concentrations in cigarette smokers.
New evidence is presented that maternal smoking reduces placental progesterone content and support the established association of smoking with placental cadmium. Expand
Combined chelation therapy in reducing tissue lead concentrations in suckling rats
The results do not support combined treatment in this age group, which is especially sensitive to trace element deficiencies, and suggest that meso‐DMSA might be the treatment of choice in acute lead poisoning in infants. Expand
Use of human milk in the assessment of toxic metal exposure and essential element status in breastfeeding women and their infants in coastal Croatia.
The levels of main toxic metals Cd, Pb and Hg and essential elements Ca, Fe, Cu, Zn and Se in maternal blood and three types of breast milk samples in the studied area of coastal Croatia showed no risk of disrupted essential element levels with regard of toxic metal exposure in both breastfeeding women and their infants. Expand
Succimer treatment and calcium supplementation reduce tissue lead in suckling rats
The effect of combined treatment with meso‐2,3‐dimercaptosuccinic acid (DMSA) and calcium supplementation in reducing lead absorption and enhancing lead elimination was evaluated in suckling ratsExpand
Organ cadmium deposits in orally exposed female rats and their pups and the depleting efficiency of sodium N‐(4‐methoxybenzyl)‐D‐glucamine‐N‐carbodithioate monohydrate (MeOBDCG)
The liver and kidney contents of Cd increased by a higher factor during lactation than during pregnancy and exposure During lactation was also more important for pups than prenatal exposure. Expand
Effect of dietary calcium on cadmium absorption and retention in suckling rats
It was concluded that calcium supplementation during the suckling period could be an efficient way of reducing oral cadmium absorption and retention without affecting tissue essential trace element concentrations. Expand
Regulation of manganese accumulation in perinatally exposed rat pups
This work aimed at collecting new data on Mn accumulation during the perinatal period by using an experimental rat model in pups whose mothers were exposed orally to Mn in drink (as manganese chloride) throughout pregnancy and 11 days of lactation. Expand