Resin-bound triphenylphosphine was coupled to 4-fluoro-3-nitrobenzyl bromide, and 2-alkylthiobenzimidazoles were synthesized on Resin in 4 steps using standard chemistries, resulting in the synthesis of an 80-member test library of high purity as determined by HPLC.
The first total synthesis of (+)-spiroindimicin A is reported, which bears a challenging C-3’/C-5’’-linked spiroindolenine, providing potential starting points for new therapeutics for the neglected tropical diseases leishmaniasis and African sleeping sickness.