• Publications
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Physics in Nuclear Medicine
TLDR
The Gamma Camera: Basic Principles and Performance Characteristics and Digital Image Processing in Nuclear Medicine: Hybrid Imaging: SPECT/CT and PET/CT.
TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD
TLDR
The data indicate that cerebral FDG-6-PO4 in humans increases for about 90 minutes, plateaus, and then slowly decreases, and that cerebral blood FDG activity levels were found to be a minor fraction of tissue activity.
Noninvasive determination of local cerebral metabolic rate of glucose in man.
TLDR
The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey and the subject-to-subject variation of LCMRGlc as measured by the present method was comparable to that of other methods that measure whole-brain CMRglc.
PET of brain amyloid and tau in mild cognitive impairment.
TLDR
FDDNP-PET scanning can differentiate persons with mild cognitive impairment from those with Alzheimer's disease and those with no cognitive impairment, and this technique is potentially useful as a noninvasive method to determine regional cerebral patterns of amyloid plaques and tau neurofibrillary tangles.
Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings.
TLDR
Subjects with MDD had regional brain metabolic abnormalities at baseline that tended to normalize with treatment, and regional metabolic changes appeared similar with the 2 forms of treatment.
Positron emission tomography provides molecular imaging of biological processes.
  • M. Phelps
  • Medicine, Biology
    Proceedings of the National Academy of Sciences…
  • 1 August 2000
TLDR
Molecular imaging by PET, optical technologies, magnetic resonance imaging, single photon emission tomography, and other technologies are assisting in moving research findings from in vitro biology to in vivo integrative mammalian biology of disease.
Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET.
TLDR
The skeletal kinetics of [18F]fluoride ion with dynamic PET imaging is investigated to generate quantitative estimates of fluoride uptake (a "bone metabolic index") in focal skeletal regions or in more generalized distributions.
Quantitation in Positron Emission Computed Tomography: 1. Effect of Object Size
TLDR
The effect of object size on the capability of positron emission computed tomography to measure isotope concentrations in a cross section was studied and measurements were found to be in good agreement with theoretical predictions for ideal systems of comparable resolution.
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET
TLDR
The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.
TLDR
In patients presenting with cognitive symptoms of dementia, regional brain metabolism was a sensitive indicator of AD and of neurodegenerative disease in general and a negative PET scan indicated that pathologic progression of cognitive impairment during the mean 3-year follow-up was unlikely to occur.
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