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Physics in Nuclear Medicine
  • 913
  • 86
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TOMOGRAPHIC MEASUREMENT OF LOCAL CEREBRAL GLUCOSE METABOLIC RATE IN HUMANS WITH (F‐18)2‐FLUORO-2‐DEOXY-D‐GLUCOSE: VALIDATION OF METHOD
Tracer techniques and quantitative autoradiographic and tissue counting models for measurement of metabolic rates were combined with positron computed tomography (PCT) andExpand
  • 1,080
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Positron emission tomography study of human brain functional development
From over 100 children studied with 2‐deoxy‐2{18F}fluoro‐D‐glucose and positron emission tomography we selected 29 children (aged 5 days to 15.1 years) who had suffered transient neurological eventsExpand
  • 1,431
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Tomographic measurement of local cerebral glucose metabolic rate in humans with (F‐18)2‐fluoro‐2‐deoxy‐D‐glucose: Validation of method
Tracer techniques and quantitative autoradiographic and tissue counting models for measuremnt of metabolic rates were combined with positron computed tomography (PCT) andExpand
  • 1,719
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Noninvasive determination of local cerebral metabolic rate of glucose in man.
A method for the determination of local cerebral metabolic rates of glucose (LCMRGlc) in normal man is described. The method employs [18F]2-fluoro-2-deoxy-D-glucose (FDG) and emission-computedExpand
  • 970
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PET of brain amyloid and tau in mild cognitive impairment.
BACKGROUND Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons with mildExpand
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Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings.
BACKGROUND In functional brain imaging studies of major depressive disorder (MDD), regional abnormalities have been most commonly found in prefrontal cortex, anterior cingulate gyrus, and temporalExpand
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Quantitation in Positron Emission Computed Tomography: 1. Effect of Object Size
The effect of object size on the capability of positron emission computed tomography to measure isotope concentrations in a cross section was studied. The relationship between the apparent isotopeExpand
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Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET.
To evaluate the feasibility of quantitatively assessing regional skeletal fluoride uptake in humans in focal and generalized bone disease, we investigated the skeletal kinetics of [18F]fluoride ionExpand
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Positron emission tomography provides molecular imaging of biological processes.
  • M. Phelps
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1 August 2000
Diseases are biological processes, and molecular imaging with positron emission tomography (PET) is sensitive to and informative of these processes. This is illustrated by detection of biologicalExpand
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