• Publications
  • Influence
Hemagglutinin-specific enzyme-linked immunosorbent assay for antibodies to influenza A and B viruses.
TLDR
The ELISA was more sensitive than the hemagglutination-inhibition assay, and the range of antibody titers measurable by ELISA in human serum was from less than 1:20 for children who had never experienced influenza infection to 1:400,000 for adults convalescing from a secondary infection. Expand
New developments in the measurement of the hemagglutinin content of influenza virus vaccines by single-radial-immunodiffusion.
TLDR
The surfactant, Emulphogene (BC-720), was found to be generally the most satisfactory of the detergents tested against a variety of vaccine strains and the zone size for B/Hong Kong and A/USSR/77 strains was finding to be unaffected by a wide range of BC-720 concentrations in contrast to the variable reaction size obtained with different concentrations of sodium sarkosyl sulfate (SSS). Expand
Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines.
TLDR
Intranasal vaccination of susceptible children with live, attenuated, cold-adapted influenza A viruses efficiently stimulates both systemic and local antibody responses, and a good correlation between the level of nasal-wash antibodies measured by the HA-specific IgA enzyme-linked immunosorbent assay and by a plaque neutralization assay is indicated. Expand
Hemagglutinin-specific antibody responses in immunoglobulin G, A, and M isotypes as measured by enzyme-linked immunosorbent assay after primary or secondary infection of humans with influenza A virus.
TLDR
There was a correlation between the presence of and the magnitude of nasal wash and serum hemagglutinin-specific IgA antibody responses in the adults undergoing secondary infection, which suggested that there was a common source for the hemagGlutin in-specific local IgA antibodies produced after infection. Expand
Antigen-specific human T lymphocyte clones: viral antigen specificity of influenza virus-immune clones.
TLDR
The fine specificity of an MP-reactive TLC was confirmed by subcloning and the five TLC recognized all the viral subtypes; the remaining clones recognized only subtypes that shared serologically defined determinants with the immunizing subtype. Expand
Secretory immunological response after intranasal inactivated influenza A virus vaccinations: evidence for immunoglobulin A memory.
TLDR
The competence of the secretory IgA immune system in young children in mounting primary and secondary responses to influenza antigens has important implications for approaches to prevention of influenzal illness. Expand
Inactivation of human T‐cell lymphotropic virus, type III by heat, chemicals, and irradiation
Abstract: Infectivity of human T‐cell lymphotropic virus, Type III (HTLV‐III) was inactivated by heat more rapidly if in liquid medium than if lyophilized and more rapidly at 60° than 56°C. WhenExpand
Mitogenicity of influenza hemagglutinin glycoproteins and influenza viruses bearing H2-hemagglutinin.
TLDR
The hemagglutinin glycoprotein is responsible for the mitogenic effect of influenza A viruses of the H2N2 subtype and is shown to be mitogenic by the ability of viruses bearing the H1N1/2/3/4/5/6/7/8/9/12/13/14/15/16/17 to induce lymphocyte proliferation in normal spleen cell suspensions. Expand
Development of subtype-specific and heterosubtypic antibodies to the influenza A virus hemagglutinin after primary infection in children.
TLDR
After primary infection with an influenza A virus, children develop enzyme-linked immunosorbent assay, but not hemagglutination inhibition, antibodies reactive with heterosubtypic HAs, which could influence the response to infection with other wild-type or attenuated vaccine strains of influenza Airus. Expand
More on partitioning and inactivation of AIDS virus in immune globulin preparations.
TLDR
Results of laboratory studies of the fractionation process and surveillance ofimmune globulin recipients corroborate epidemiologic observations indicating that receipt of immune globulin is not associated with the risk of the development of AIDS. Expand
...
1
2
3
...