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CAVER: a new tool to explore routes from protein clefts, pockets and cavities
TLDR
We develop and implement an algorithm for the rapid, accurate and automated identification of paths leading from buried protein clefts, pockets and cavities in dynamic and static protein structures to the outside solvent. Expand
MOLE: a Voronoi diagram-based explorer of molecular channels, pores, and tunnels.
TLDR
We have developed an algorithm, "MOLE," for the rapid, fully automated location and characterization of molecular channels, tunnels, and pores, which is applied to a Voronoi mesh. Expand
Serum Levels of the MCP-1 Chemokine in Patients With Ischemic Stroke and Myocardial Infarction
Chemokine-driven migration of inflammatory cells has been implicated in pathogenesis of atherosclerosis-associated conditions such as ischemic stroke and myocardial infarction. In this study, aExpand
Ace gene I/D polymorphism and sarcoidosis pulmonary disease severity.
Previous studies of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversyExpand
The MCP‐1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
Monocyte chemoattractant protein (MCP)‐1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) andExpand
Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis.
Bone remodeling is a tightly coupled process consisting of repetitive cycles of bone resorption and formation. Both processes are governed by mechanical signals, which operate in conjunction withExpand
Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia.
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies indicated the increased blood levels of proinflammatory interleukin-6 cytokine in schizophrenia. However,Expand
CC and C chemokine expression in pulmonary sarcoidosis
The chemokines RANTES (regulated on activation, T-cell expressed and secreted; CC chemokine ligand (CCL)-5) and monocyte inflammatory protein (MIP)-1α (CCL-3) have been implicated in the developmentExpand
CC chemokine receptor gene polymorphisms in Czech patients with pulmonary sarcoidosis.
Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotacticExpand
Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis.
Genetic factors, in particular human leukocyte antigens (HLAs) are important determinants of susceptibility to sarcoidosis, a chronic granulomatous disease of undetermined etiology. To clarify theExpand
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